_Symptoms._ Diarrhœa is a common premonitory symptom arising from the irritation of the intestinal canal as it is soon followed by some degree of costiveness, the dung becoming dark colored, firm and scanty. Diarrhœa reappears later. The coat stares or the beast actually shivers; the head is depressed; the roots of the horns and the forehead are hot; the eyes are sunken, swollen and red, suffused with tears, turbid in their anterior chamber (aqueous humor) and intolerant of light; The muzzle dry and hot; the mouth hot but moist with abundant saliva; the mucous membranes of the mouth, nose and vagina have a bluish red color; the pulse is rapid and more or less full or hard; impulse of the heart weak; the breathing is accelerated, the respiratory sound is heightened in intensity and a cough is frequent. Temperature 104° to 107° F. The urine is scanty and high colored. The surface of the body is alternately hot and cold, and after some time a watery fluid begins to distil from the nose. At the end of twenty-four hours the symptoms are intensified or altered. The eyelids are more swollen and the flow of tears more profuse; the nasal discharge becomes slimy, and streaked with blood, and accumulations take place in the frontal sinuses as indicated by the increasing heat of the forehead and the dullness on percussion. In the mouth appear dark red spots, from blood extravasation, over which the epithelium sloughs off leaving raw unhealthy sores. The appetite entirely fails; dung and urine are passed painfully and with effort, and abortion frequently takes place in pregnant cows. The urine is albuminous with cell forms, and casts. The limbs appear rigid and it pains the animal to move. From the fourth to the sixth day the ulceration appears on the mucous membrane of the nose which has often a claret color, and the nasal discharge becomes again more watery and irritating. The muzzle is swollen and a dropsical infiltration appears beneath the jaws which extends along the neck to beneath the thorax and into the limbs. Portions of the nasal mucous membrane now slough off, and similar sloughs are often seen on the skin of different parts of the body; the secreting structures of the horns and hoofs even participating so that these are easily detached or shed. Saliva flows profusely from the lips, a fetid watery diarrhœa succeeds the constipation, the dropsy becomes nearly general and death occurs on the eighth, ninth or tenth day of the illness. Convulsions and symptoms of suffocation may precede death.