_Symptoms._ These may set in just after birth but usually the disease occurs within the two first weeks of life. When delayed for a few days after birth it may be preceded by some constipation, the fæces appearing hard, moulded, and covered with mucus. This is especially the case when the meconium has been retained and has proved a cause of irritation. The young animal is careless of the teat or refuses it (or the pail if brought up by hand), yawns and seems weary. The abdominal muscles are tense and the belly may be swollen if fermentation has already set in but this is rarely excessive. Straining to defecate usually causes eructations of an acid odor, and sometimes vomiting of solid soursmelling clots. Abdominal pain may be manifested by uneasy movements of the tail and hind limbs, by looking toward the flank and even by plaintive cries. This is followed within six hours by liquid dejections, at first merely soft, slimy and sour but soon complicated by a peculiar odor of rotten cheese which becomes increasingly offensive as the malady advances. The tail and hips become soaked with the discharges and as the putrid fermentation goes on after their discharge of the fæcal matters, the air becomes more and more repulsive. The same odor pervades the mouth and the breath and the tongue is coated with a whitish, grayish or yellowish fur. The fæces become more watery and slimy, with much casein in course of putrefaction, and the patient is rapidly run down by the profuse discharge and the general poisoning by absorbed putrid products. In the worst cases this may prove fatal in one or two days. When the illness is more prolonged the alvine passages which at first number five or six per day, increase to fifteen or twenty and are passed with more effort, usually leaving the anus in a liquid stream. The color of the stools changes from a yellow to a grayish yellow or dirty white, hence the common name of _white scour_, and the fœtor is intensified. Appetite may be in part preserved for a time but is gradually lost, and the subject becomes dull, listless and weak, indisposed to rise and walking unsteadily when raised. A general appearance of unthriftiness, staring coat, scurfy, unhealthy skin, pallor of the mucous membranes, arching of the back, tucking up and tenderness of the abdomen, excoriation of the margins of the anus, and congestion of the rectum as seen everted during defecation, mark the advance of the disease. Emaciation becomes very marked, and weakness and prostration extreme. Fever usually sets in as the disease advances, as marked by hyperthermia, hot dry muzzle, hot ears, accelerated pulse and breathing. When the intestinal fermentation is extreme there may be distinct bloating, more acute colicy pains, rumbling of the bowels and a frothy and even bloody condition of the dejections. The prostration may become extreme and the temperature reduced to the normal or below.