Wounds implicating nerves, and tumors pressing on nerves, have served as sources of nervous excitement which accumulates in the cerebral ganglia and bursts forth as an epileptic explosion. Bourgelat mentions the case of a horse which fell in a fit the moment he was touched on his tender withers, also a case in which a seizure coincided with an attack of recurrent ophthalmia. Gerlach saw a horse which had an epileptic fit the instant he was touched on his sensitive withers. In kittens and puppies the irritation attendant on dentition is a common cause of attacks. In nervous dogs and pigs indigestion or constipation may serve as the occasion of an explosion. In the experimental cases of Brown-Sequard, not only did the injury to the sciatic nerve develop in the brain a latent tendency to epilepsy, but the subsequent pinching of the skin in certain areas (epileptigenous zones) promptly brought about a seizure. =Causes.= Most of the causes of epilepsy have been given above under the head of pathology and morbid anatomy. The nervous predisposition may, like any other peculiarity or function, become hereditary. In the human race nothing is more certain than the tendency to some form of nervous disorder (insanity, dementia, alcoholism, morphinism, epilepsy, chorea, etc.) in a special family line. Reynal records the case of an epileptic cat (belonging to an employe of the Alfort veterinary school) the progeny of which for three generations, became affected with epilepsy and mostly died before they were a year old. Also four epileptic dogs (3 males and 1 female) which produced a number of epileptic puppies. LaNotte records the cases of two bulls affected with epilepsy, in the progeny of which numerous cases of epilepsy appeared; the cows being attacked after the first calving, and the oxen soon after they were first put to work. Breeding stallions are particularly liable to attacks, the high feeding, lack of muscular work in the open air, and above all the oft repeated nervous excitement attendant on copulation being directly exciting causes. The heredity of the artificial epilepsy induced by Brown-Sequard in Guinea pigs, serves to strengthen the doctrine of heredity in ordinary forms.