Some marked change in the disposition or habits of the animal is the first obvious variation from health, and in a district or country where rabies exists any such change should be the warrant for instant seclusion of the dog before there is any disposition to bite. The unwonted habit may be of almost any kind. The lively, amiable dog may become suddenly dull, apathetic or taciturn; the quiet, unexcitable dog may become unusually affectionate, fawning and demonstrative, licking the owner’s hands and face and perhaps infecting him before any suspicion is aroused. Sudden capricious changes from fawning to apathy or sullenness, or the opposite, should be dreaded. The noisy dog may become suddenly silent; while the silent dog may take to howling without apparent cause. A great restlessness, watchfulness or nervousness, a tendency to start at the slightest sound, and a disposition to move at frequent intervals in search of an easier position or place to lie in, are most dangerous symptoms. A morbid appetite, with a disposition to pick up and swallow all sorts of nonalimentary objects (straw, thread, cord, paper, pins, nails, coal, marbles, pebbles, cloth, earth, dung or urine), in a mature dog is most suggestive. Searching around, scraping, tearing sticks, clothes and other objects to pieces, licking of smooth cold stone or metal, of his penis, or of the generative organs of a bitch, are often early phenomena. The dog may hide in a dark corner, going to sleep and grumbling or growling when disturbed. He may make night hideous with his howls, _baying at the moon_. He may stand with a dull, melancholy, hopeless expression of countenance, as if beseeching his master for relief from his nameless suffering. But as yet there is no disposition to bite. The dog still responds to the call of the master, but with dulness and apathy, in marked contrast with his usual prompt, alert and loving response. There may be congestion, itching and irritation in the seat of the bite, and it may be licked, scratched or gnawed until raw, tender or bleeding. An early change in the voice may be noticeable. There is at first a certain hoarseness, which gradually develops into the pathognomonic rabid howl which is quite recognizable at a distance. The dog turns his nose upward, and with open mouth, emits a howl which, at first hoarse and low, rises into a shriller and higher note before completion and which may be repeated several times without closing the mouth. It is not an ordinary howl but rather a cry of distress, and, to the educated ear a grave note of warning. Sometimes the dog is dumb from the start.