The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
Salines are hydragogue. Requiring water for their proper solution, and
having further a great affinity for it, they convey a large quantity of
the aqueous part of the blood with them through the glands of the
bowels. When their action is very powerful, some of the albumen of the
blood may be purged away along with this. This may also take place with
the drastic resinous Cathartics. But the latter are much more violent in
their action, producing a degree of griping and irritation which is
dangerous in febrile cases. Salines, on the contrary, are cooling, and
mild in their operation. They are appropriate in inflammations, not only
for this reason, but because, while passing through the blood, they
exert in it, as we have already seen, a mild action of an antiphlogistic
nature. (_Vide_ page 188.)
When the vegetable salts of the alkalies are given in diuretic doses
they are decomposed into carbonates while in the system. This does not
appear to be the case when they are given in such quantity as to pass
off quickly by the bowels.
These various Cathartic medicines are affirmed to act on the eliminative
principle: it follows then that they must themselves pass out of the
body along with the secretion which is augmented by their action. It is
natural that the fæces should have been less examined than other
secretions. The resins of Jalap, Scammony, and other such substances,
are affirmed to pass out along with them. Of the passage of saline
Purgatives we have an indirect proof; which is, that after their
administration the amount of saline matter in the urine is not
materially increased. Castor-oil is seen in the evacuations, sometimes
little altered, at other times in the form of a solid fatty substance.
M. Lehmann has detected Mercury in the fæces, whenever it was given as a
Purgative, and whatever the colour of the evacuation. When combined with
a sufficient amount of Opium, it neither acts as a Purgative, nor does
it pass out by the bowels; and it has therefore in that case a better
opportunity of exerting its operation in the blood. We always find that
when a Cathartic passes off in some other way than by the glands of the
bowels, it fails to produce purging. Thus a copious dilution with water
may sometimes cause it to be excreted by the kidneys, which are the
natural emunctories of water. In some persons that are wont to perspire
very freely it is difficult to produce purging. The case related by Dr.
Ward of a woman with whom a dose of Castor-oil was seen to pass off by
the skin, and invariably failed to act on the bowels, is an extreme
instance of this kind.
Of what use and intention, we may now venture to ask, is this intestinal
function, the continual maintenance of which in a healthy condition is
found to be so essential?
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