The involuntary organs do not sleep until death ends our earth life. We can readily understand that if by any cause polarity in the two large poles in the cerebrum are reversed, the gateway by which we gain a knowledge of things about us is closed so perfectly that physical sensation is impossible. On the other hand, if the equilibrium between the two large poles in the cerebellum are not well balanced, just in this proportion some kind of ailment is the result. Let us not forget that the will has no control over these poles, and all medicine that does not beneficially act on them is non-curative. Now, just in proportion as anæsthetic agents disturb their equilibrium, they are dangerous, it makes no difference whether polarity is reversed or destroyed; in either case the principle of life can no longer act on the nerves by means of its intermediate; the heart ceases to beat, and restoration is impossible. Chloroform is more easily administered than ether or gas, and most convenient when the patient cannot come to the office; but we should remember that many deaths have occurred when given for the purpose of extracting teeth, and that, too, when least expected. The public mind is more horrified at one death in the dentist's office than twenty caused by a railroad smash-up. We have now the means that will stimulate the nerves, greatly mitigate the pain and not endanger either life or health. I have long desired a perfectly safe anæsthetic that can be administered no matter what the condition of the patient. I am now creditably informed that Dr. Mayo, of Boston, some eighteen months ago, by various experiments, produced a compound article that satisfied him was harmless. He would not put it on the market until it had been thoroughly tested by both dentists and surgeons. All who tested its effect and efficiency testified to its great superiority over all other known anæsthetics for dental and minor surgical operations. It is now only a few months since he made arrangements for its manufacture and appliances, and put it on the market. He has named it Mayo's Vegetable Vapor Anæsthetic. I have been using it for extracting teeth very successfully. The nitrous oxide causes the patient, when fully under its influence, to have very like the appearance of a corpse. The action of this new anæsthetic does not act on the vital organs, and the patient appears like one in a natural sleep, and, in my opinion, is perfectly safe and without danger to life or health. Our patients come to us for either a preventative or curative treatment. As before said, we are brought face to face with almost every conceivable condition of the nervous system, and the more true knowledge we have of it the better are we able to satisfactorily manage them. Some come in a very excitable, and some in a very depressed state. We need means to quiet the former and stimulate the latter.