Epicarin, C_{6}H_{3}(OH)(COOH) (CH_{2}C_{10}H_{6}OH) 2:3:1 =
C_{18}H_{14}O_{4}, β-naphthol-hydroxy-toluic acid.
Actions and Uses.—Epicarin is a non-poisonous antiseptic and
parasiticide. Administered internally, it is excreted mostly
undecomposed. It has been found useful in the treatment of
skin-diseases, particularly scabies, tinea tonsurans, prurigo and
certain forms of eczema. Dosage.—It is used externally only in the form
of 5 to 20 per cent. ointment, with petrolatum or wool fat (lanolin) as
base, or in the form of oily or alcoholic solutions (10 per cent.).
Manufactured by Farbenfabriken, vorm. Friedr. Bayer & Co., Elberfeld,
Germany (Continental Color and Chemical Co., New York).
ERYTHROL TETRANITRATE.
Erythrol tetranitrate, C_{4}H_{6}(NO_{3})_{4} = C_{4}H_{6}O_{12}N_{4},
the tetranitrate of erythrite or butane-tetrol, C_{4}H_{6}(OH)_{4}.
Actions and Uses.—It is a vasodilator and antispasmodic, like
nitroglycerin. Its action is slower and more lasting; it begins in 15
minutes and persists for three or four hours. It is recommended in
angina pectoris and cardiac diseases. It is reported as especially
useful as a prophylactic in preventing anginal pain. Dosage.—Because of
its explosiveness it is marketed in the form of tablets, each containing
0.03 gramme (½ grain). One or two tablets every four to six hours.
Manufactured by E. Merck, Darmstadt (Merck & Co., New York).
ETHYLENEDIAMINE.
Ethylenediamine, C_{2}H_{4}(NH_{2})_{2}, a substitution compound of
ethylene and ammonia.
Actions and Uses.—It is said to be non-corrosive. It is recommended as
an albumin solvent for the solution of false membranes in diphtheria and
similar affections of the mucous membranes. It is recommended for use in
the form of kresamine (which see). Manufactured by Chemische Fabrik auf
Actien, vorm. E. Schering, Berlin (Schering & Glatz, New York).
EUCAINE.
The “Eucaines” are two closely allied synthetic bases, which were
originally differentiated as eucaine “A” and eucaine “B,” but are now
designated as “Alpha-eucaine” and “Beta-eucaine,” respectively,
alpha-eucaine being a synthetic derivative of triacetonamine, while
beta-eucaine is a synthetic derivative of vinyl-diacetonekalmine. Both
of these bases are supplied as hydrochlorides and are recommended as
substitutes for cocaine, over which they are claimed to have certain
advantages. They are described under alpha-eucaine hydrochloride and
beta-eucaine hydrochloride.
(_To be continued._)
_Report of the Council on Pharmacy and Chemistry, from the Journal A. M.
A., October 20, 1906._
TYREE’S ANTISEPTIC POWDER.
Tyree’s antiseptic powder was assigned for examination to a subcommittee
of the Council, which made the following report:
Public-domain text, read in full here on John Shaqi.
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