The American Therapist. Vol. II. No. 7. Jan. 15th, 1894: A Monthly Record of Modern Therapeutics, with Practical Suggestions Relating to the Clinical Applications of Drugs.Various
Science
The American Therapist. Vol. II. No. 7. Jan. 15th, 1894: A Monthly Record of Modern Therapeutics, with Practical Suggestions Relating to the Clinical Applications of Drugs.
Various
Drug utilization -- Periodicals; Drugs -- Periodicals
About thirty distinct experiments were tried on ten different animals,
with only two or three negative results to fifty positive ones. The
results, taken collectively, plainly indicate that the increase in the
number of leucocytes in the circulating blood, after the ingestion of
food, is very marked, the maximal increase being 146 per cent., while
the average increase amounted to 78 per cent. This, as Pohl states,
would indicate for the total content of blood in an animal an increase
in some cases of 1,000,000,000 of leucocytes. Control experiments showed
that, normally, there were only comparatively small variations in the
content of leucocytes in the blood, from hour to hour, in the absence of
food. It is to be further observed that this marked increase in the
number of white corpuscles in the circulating blood, after the ingestion
of food, usually reaches its maximum in the third hour, _viz._: at a
time when digestion would most probably have reached its height, no
noticeable change being usually observed before the end of the first
hour after the taking of food. Evidently, some transformation-products
of the ingested food must be formed before leucocytosis becomes marked.
The return to the normal number of leucocytes shows no regularity; in
some cases being very gradual, in others quite rapid.
This marked action of food in increasing the number of leucocytes in the
circulating blood, naturally raises the question whether all varieties
of food possess this power, or whether it is limited to some one or more
individual food-stuffs. In attempting to answer this question, Pohl
tried a large number of experiments, the results of which afforded proof
that neither water, salts, fats, carbohydrates, or even meat extracts,
are able to materially affect the number of leucocytes in the blood.
Proteid-containing foods, on the other hand, such as meat, Witte’s
peptone, and gelatin peptone quickly raise the content of white blood
corpuscles to a marked degree. Somewhat noticeable was the result
obtained on feeding wheat bread. This food-stuff, in spite of its fairly
large content of proteid matter, failed to exert any influence on the
number of leucocytes in the blood, and in conformity with this result it
was found that in herbivorous animals there was an utter lack of
anything approaching a digestive leucocytosis, even after protracted
fasting.
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