The American Therapist. Vol. II. No. 7. Jan. 15th, 1894: A Monthly Record of Modern Therapeutics, with Practical Suggestions Relating to the Clinical Applications of Drugs.Various
Science
The American Therapist. Vol. II. No. 7. Jan. 15th, 1894: A Monthly Record of Modern Therapeutics, with Practical Suggestions Relating to the Clinical Applications of Drugs.
Various
Drug utilization -- Periodicals; Drugs -- Periodicals
The facts would thus seem to warrant the assertion that, as a rule, the
venous blood flowing from the intestinal tract of an animal, fed on a
rich proteid diet, contains a much larger number of leucocytes than the
arterial blood flowing to the intestine; although, if space permitted,
we might instance certain occasional exceptions due to various causes,
which, however, do not reflect against the view that there is a marked
production of leucocytes in the lymph spaces surrounding the intestine,
and in the lymph glands of the mesentery, as a normal accompaniment to
digestive proteolysis.
Taking into account all of the circumstances attending the circulation
of the blood through the abdominal organs, especially the rate of flow,
and remembering the great increase in the number of leucocytes contained
in the blood during the several hours attending digestive proteolysis,
it is plain that a comparatively large amount of proteid matter must be
transferred from the intestine to the blood in the bodies of the white
corpuscles so abundantly produced in the lymph glands, etc., during
proteid digestion. Indeed, Pohl calculates, on the basis of his own and
the observations of others, that in the case of an animal weighing 5
kilograms, and fed with 100 grams of fresh beef, containing 20 grams of
proteid matter, the entire amount of albumin required to supply the loss
incidental to the normal physiological processes of the body could be
absorbed into the circulation from the intestine in the form of
leucocytes, assuming a digestive period of six hours. Moreover, the
evidence acquired from Pohl’s experiments of the enormous production of
new cells in the intestinal walls during the height of digestion renders
such a theory of the transference of proteid matter from the alimentary
tract to the tissues and fluids of the body quite plausible. At the end
of twenty-four hours the leucocytes have fallen back to their normal
number, having presumably been broken down in the blood-plasma or
dissolved in the tissues and organs, thus giving up the proteid matter,
of which they are composed, for the general nourishment of the body.
Obviously, we can not admit that all the proteid matter of the food is
absorbed in the form of leucocytes, for, as we know, some at least of
the proteid food ingested is carried beyond the peptone stage, either
through the action of trypsin, or through the action of the organized
germs in the intestine, but we can certainly accept the views so
admirably worked out by Pohl, in so far as they indicate one way in
which proteid matter may pass from the intestine into the blood, after
having undergone a preliminary transformation in the alimentary tract
into primary albumoses and peptone. Again, if Pohl’s views are correct,
we see that the proteid foods are quickly transformed into organized
material in the body of the lymph cell prior to their absorption into
the blood, a view which is in harmony with the long-known fact that
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