When two stimuli occur together, one of them, occurring afterwards, may call out the reaction for the other also. We call this an "ekphoric influence," and stimuli having this character are called "ekphoric stimuli." In such a case we call the engrams of the two stimuli "associated." All simultaneously generated engrams are associated; there is also association of successively aroused engrams, though this is reducible to simultaneous association. In fact, it is not an isolated stimulus that leaves an engram, but the totality of the stimuli at any moment; consequently any portion of this totality tends, if it recurs, to arouse the whole reaction which was aroused before. Semon holds that engrams can be inherited, and that an animal's innate habits may be due to the experience of its ancestors; on this subject he refers to Samuel Butler. Semon formulates two "mnemic principles." The first, or "Law of Engraphy," is as follows: "All simultaneous excitements in an organism form a connected simultaneous excitement-complex, which as such works engraphically, i.e. leaves behind a connected engram-complex, which in so far forms a whole" ("Die mnemischen Empfindungen," p. 146). The second mnemic principle, or "Law of Ekphory," is as follows: "The partial return of the energetic situation which formerly worked engraphically operates ekphorically on a simultaneous engram-complex" (ib., p. 173). These two laws together represent in part a hypothesis (the engram), and in part an observable fact. The observable fact is that, when a certain complex of stimuli has originally caused a certain complex of reactions, the recurrence of part of the stimuli tends to cause the recurrence of the whole of the reactions. Semon's applications of his fundamental ideas in various directions are interesting and ingenious. Some of them will concern us later, but for the present it is the fundamental character of mnemic phenomena that is in question. Concerning the nature of an engram, Semon confesses that at present it is impossible to say more than that it must consist in some material alteration in the body of the organism ("Die mnemischen Empfindungen," p. 376). It is, in fact, hypothetical, invoked for theoretical uses, and not an outcome of direct observation. No doubt physiology, especially the disturbances of memory through lesions in the brain, affords grounds for this hypothesis; nevertheless it does remain a hypothesis, the validity of which will be discussed at the end of this lecture.