(5) Silcock’s Case (London).[181] The patient, aged 50, who had fallen ill with serious symptoms, exhibited fever, enlarged liver and spleen, and had a dry, coated tongue. At the autopsy numerous caseous centres, mostly immediately beneath the surface, were found, while the contiguous parts of the liver were inflamed. Microscopical examination demonstrated numerous Coccidia in the hepatic cells as well as in the epithelium of the biliary ducts. A deposit of Coccidia was likewise found in the spleen, which the parasites had probably reached by means of the blood-stream.[182] [181] Silcock, “A Case of Parasit. by Psorospermia,” _Trans. Path. Soc._, London, 1890, xli, p. 320. [182] Pianese has confirmed the fact that Coccidia actually occur in the blood of the hepatic veins of infected rabbits. (_b_) *Human Intestinal Coccidiosis.* In two cadavers at the Pathological Institute in Berlin, Eimer[183] found the epithelium of the intestine permeated by Coccidia. Railliet and Lucet’s case may be traced back to intestinal Coccidia, which were found in the fæces of a woman and her child, who had both suffered for some time from chronic diarrhœa.[184] In other cases (Grassi, Rivolta), where only the existence of Coccidia in the fæces was known, it is doubtful whether the parasites originated in the intestine or in the liver. [183] _Die ei- u. kugelf. Psorosp. d. Wirbelt._, 1870, p. 16. [184] Railliet and Lucet, “Obs. s. quelq. Cocc. intest.,” _C. R. Soc. Biol._, Paris, 1890, p. 660; Railliet, _Trait. Zool. med. et agric._, 2e éd., 1895, p. 140. (_c_) *Doubtful Cases.* To these belong Virchow’s case[185] where, in the liver of an elderly woman, a thick walled tumour measuring 9 to 11 mm. was found. Among the contents of this tumour there were oval formations 56 µ long, surrounded by two membranes and enclosing a number of round substances. Virchow considered these foreign bodies to be eggs of pentastomes in various stages of development, others consider them to be Coccidia. [185] _Arch. f. path. An._, xviii, 1860, p. 523. The Coccidia which Podwyssotzki claims to have seen in the liver of a man, not only in the liver cells, but also in the nuclei, are also problematic.[186] The parasite was called _Caryophagus hominis_. [186] Podwyssotzki, “Ueb. d. Bedeut. d. Coccid. in d. Path. Leber des Menschen,” _Centralbl. f. Bakt._, vi, 1889, p. 41. Again, other explanations can be given to an observation by Thomas, on the occurrence of _Coccidium oviforme_ in a cerebral tumour of a woman aged 40. The growth was as large as a pea and surrounded by a bony substance.[187] [187] Thomas, J., “Case of Bone Formation in the Human Brain, due to the Presence of _Coccidium oviforme_,” _Journal Boston Soc. Med. Sc._, iii, 1899, p. 167; _Centralbl. f. Bakt._ [I] xxviii, 1900, p. 882. Genus. *Isospora*, Aimé Schneider, 1881. Syn.: _Diplospora_, Labbé, 1893.