The period of time generally denominated the Middle Ages commences with the fifth century, and ends with the fifteenth. We have in several instances ventured to extend the limits as far as a part of the sixteenth century, and therefore include among female artists the name of Sofonisba Anguisciola, who was born about 1540. She was a noble lady of Cremona, whose fame spread early throughout Italy. In 1559, Philip II. of Spain invited her to his court at Madrid, where on her arrival she was treated with great distinction. Her chief study was portraiture, and her pictures became objects of great value to kings and popes. Her royal patrons of Spain married their artist to a noble Sicilian, giving her a dowry of twelve thousand ducats and a pension of one thousand ducats, beside rich presents in tapestries and jewels. She went with her husband to Palermo, where they resided several years. On the death of her husband the king and queen of Spain urged her to return to their court; but she excused herself on account of her wish to visit Cremona. Embarking on board a galley for this purpose, bound to Genoa, she was entertained with such gallantry by the captain, Orazio Lomellini, one of the merchant princes of that city, that the heart of the distinguished artist was won, and she gave him her hand on their arrival at Genoa. History does not tell us whether she ever revisited Cremona, but she dwelt in Genoa during the remainder of her long life, pursuing her art with great success. On her second marriage, her faithful friends in the royal family of Spain added four hundred crowns to her pension. The Empress of Germany visited Sofonisba on the way to Spain, and accepted from her hand a little picture. Sofonisba became blind in her old age, but lost no other faculty. Vandyck was her guest when at Genoa, and said that he had learned more of his art from one blind old woman than from any other teacher. A medal was struck in her honor at Bologna. The Academy of Fine Arts at Edinburgh contains a noble picture by Vandyck, painted in his Italian manner. It represents individuals of the Lomellini family, and was probably in progress when he visited this illustrious woman, who had become a member of that house.