The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic Development — John Shaqi
The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic DevelopmentHertwig, Oscar
Science
The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic Development
Hertwig, Oscar
Developmental biology; Embryology; Genetics
'The disintegration of the germplasm,' says Weismann,[7] 'is a wonderfully
complicated process; it is a true "development," in which the idic stages
necessarily follow one another in a regular order, and thus the thousands
and hundreds of thousands of hereditary parts are gradually formed, each in
its right place, and each provided with the proper determinants. The
construction of the whole body, as well as its differentiation into parts,
its segmentation, and the formation of its organs, and even the size of
these organs--determined by the number of cells composing them--depend upon
this complicated disintegration of the determinants in the id of germplasm.
The transmission of characters of the most general kind--that is to say,
those which determine the structure of an animal as well as those
characterising the class, order, family, and genus to which it belongs--are
due exclusively to this process.'
This mechanism of differentiating division fails to explain the phenomena
of reproduction and of regeneration. For these Weismann has the following
ancillary suppositions:
The first is the already-described hypothesis of continuity of the
germplasm. As the disintegration of the germplasm into determinants,
occurring in the development of an egg into an organism, is a process which
cannot be retraced, and, as the future reproductive cells of the organism
must contain undisintegrated, perfect germplasm, it follows that the
germplasm in the germ-cells of the child must have come directly from the
original germplasm of the parent. During the development, as Weismann
assumes, only a few of the ids, each of which contains all the necessary
germs, break up by differentiating division into the determinants which
control the course of the ontogeny, and decide the final characters of the
cells. Another set of ids remains undisintegrated, with their determinants
fast bound together, and, in the cell divisions, is not broken up into
dissimilar groups. The first set of ids is the active, disintegrating
germplasm; the second set is a passive, latent germplasm, which may be
described as accessory germplasm (_Nebenkeimplasma_). The active ids are
his explanation of the embryonic events, which they direct; the accessory
germplasm is reserved to form the germ-cells, and, in fast-bound condition,
is handed on through a short or long series of cell-divisions alongside the
active germplasm. Handed on in this passive state, it finally reaches a
group of cells which may be many or few generations distant from the
original egg-cell, and impresses upon them the character of sexual cells.
This transfer of germplasm from the egg to the sexual cell occurs in
orderly fashion, along prescribed series of cells which Weismann has called
the germ-tracks. Only these cells, which contain part of the perfect,
undisintegrated germplasm, serve for the preservation of the species and
are immortal; the other cells, since, from the disintegration due to
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