The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic DevelopmentHertwig, Oscar
Science
The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic Development
Hertwig, Oscar
Developmental biology; Embryology; Genetics
In spite of this purely arbitrary, complementary hypothesis, the facts seem
to me to show that Weismann assumed an untenable position when he
attributed a reserve army of 'stable plasma' only to the sets of cells in
which it was necessary to suppose its existence. The experiments of
Driesch, Wilson, and myself show that a complete embryo may spring from a
half or quarter of the egg, and that the set of nuclei first to arise may
be shifted about in the egg like a heap of billiard-balls. In the face of
such facts there seems nothing left for the theory of Weismann but to endow
every cell with accessory germplasm to prepare it for unforeseen events.
This, however, would sterilize the other part of the theory, the doctrine
of determinants, and the mechanism of development dependent on a rigid
architecture of the germplasm. Consider the confusion that would arise when
the deploying of the active army was disarranged by external influences,
now in one fashion, now in another, if the reserve army, with its store of
latent rudiments, had to come to the help of the broken pieces. What would
compel the rudiments disposed to activity according to the prearranged plan
to become latent where they were no longer wanted? And what would stir into
activity in the necessary places the originally quiescent rudiments of the
reserve army? In fact, if the _rôles_ of activity and quiescence are even
once to be exchanged by the rudiments in the cell, what object is there in
drawing a distinction so sharp between the two armies--the active army
which carries out the process of development according to a plan
prearranged in its minutest details, and a passive reserve army ordered
into quiescence and carried as baggage?
But here we come upon the scarlet thread that continuously has traversed
the theory of germplasm in all its changes. Weismann attaches the greatest
importance to the distinction. The twofold nature of the process of
development is a cardinal point in his theory, linked to his doctrine of
immortality for unicellular organisms and germ-cells and mortality for
somatic cells.
Between somatic cells and reproductive cells Weismann places a gulf that
cannot be bridged. Only the reproductive cells contain real germplasm, and
only these contain the conditions for maintaining the species, as they
alone serve for the starting of new generations of development. The somatic
cells, on the other hand, are endowed only with fragments of germplasm, and
hence they are incapable of preserving the species, and are doomed to
death. The reproductive cells, like unicellular organisms, are regarded as
immortal, the somatic cells as mortal. According to Weismann, cells cannot
pass from the one category to the other.
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