To become infected it is not necessary that there be an abrasion of the mucous membrane. The disease manifests itself in from three to seven days after exposure by swelling of the orifice of the urethra, peculiar sensations between tickling and itching, and smarting or burning during urination. The peculiar sensations fix the attention to the genitals, thus causing frequent passage of urine. These symptoms increase for about a week, when the disease reaches its maximum degree of severity, which is maintained a variable time, the discharge from the urethra being thick, creamy and of a greenish yellow color. In the majority of carefully treated cases, the discharge ceases in from three to six weeks with apparent recovery. Unfortunately, however, there is frequently a tendency for the disease to become chronic. The discharge becomes thin and more watery and persists for an indefinite period. This condition--chronic gonorrhea--is commonly known as "gleet." c. =Syphilis=, popularly termed the "pox," is a constitutional affection of the type known as "blood diseases." It is by far the most important and most greatly to be feared of the venereal diseases. No disease has been so wide-spread in its dissemination or more potent in its influence upon humanity. It has been known for centuries, having been mentioned by Japanese historians and in Chinese writings two thousand years ago. Syphilis is contagious and is transmitted by inoculation. The infectious material enters the broken surface of either the skin or mucous membrane, called "contact" or "acquired" syphilis. When it is transmitted by the mother to the embryo, it is called "hereditary" or "inherited" syphilis. The disease manifests itself first in a "_primary lesion_" which is a local ulcer (hard chancre) at the point or points of inoculation at a period ranging from ten to thirty days after exposure. It may appear as an erosion or as a dry scaling and indurated papule, varying in size from a pin-head to a silver dollar. The base of the ulcer is indurated. It is oval in shape, perhaps somewhat irregular, with a raw surface and red colored base devoid of pus. Immediately following the appearance of the chancre, the glands in direct connection with it become enlarged, hard and rarely painful, but they have no tendency to suppurate like the enlarged glands of chancroid.