The next step in Cerebral Localisation was made by a French physician, Marc Dax, who first observed that disease of the left half of the cerebrum producing paralysis of the right half of the body (right hemiplegia) was associated with loss of articulate speech. This observation led to the establishment of a most important fact in connection with speech, viz. that right-handed people use their left cerebral hemisphere as the executive portion of the brain in speech. Subsequently it was shown that when left-handed people were paralysed on the left side by disease of the right hemisphere, they lost their powers of speech. But the great majority of people are born right-handed, consequently the right hand being especially the instrument of the mind in the majority of people, the left hemisphere is the leading hemisphere; and since probably specialisation of function of the right hand (dexterity) has been so closely associated with that other instrument of the mind, the vocal instrument of articulate speech, the two have now become inseparable; for are not graphic signs and verbal signs intimately interwoven in the development of language and human intelligence? What has determined the predominance of the left hemisphere in speech? I can find no adequate anatomical explanation. There is no difference in weight of the two hemispheres in normal brains. Moreover, I am unable to subscribe to the opinion that there is any evidence to show that the left hemisphere receives a larger supply of blood than the right. Another theory advanced to explain localisation of speech and right-handedness in the left hemisphere is that the heavier organs, lung and liver, being on the right side have determined a mechanical advantage which has led to right-handedness in the great majority of people. This theory has, however, been disposed of by the fact that cases in which there has been a complete transposition of the viscera have not been left-handed in a larger proportion of cases. The great majority of people, modern and ancient, civilised and uncivilised, use the right hand by preference. Even graphic representations on the sun-baked clay records of Assyria, and the drawings on rocks, tusks, and horns of animals of the flint-weapon men of prehistoric times show that man was then right-handed. There is a difference of opinion whether anthropoid apes use the right hand in preference to the left. Professor Cunningham, who made a special study of this subject, asserts that they use either hand indifferently; so also does the infant at first, and the idiot in a considerable number of cases. Then why should man, even primitive, have chosen the right hand as the instrument of the mind? Seeing that there is no apparent anatomical reason, we may ask ourselves the question: Is it the result of an acquired useful habit to which anatomical conditions may subsequently have contributed as a co-efficient? Primitive man depended largely upon gesture language, and the