iodides are distinctly mischievous to the malignant growth, and should not be given. It is probable that the same close connections obtain between cancer and syphilis of the rectum as has been here noted in the case of the mouth, but observations on this point are too few to be of value. A very full bibliography is added to this careful paper. E. G. L. ON ADENOMA SEBACEUM. BUSCHKE. (_Derm. Zeitschr._, Bd. xi., Heft 7, p. 467.) The patient was a boy, aged 13 years, in whom the eruption of small tumours had occurred at the age of five, coming out suddenly after an attack of measles. The distribution and appearance of the single lesions on the face was of the characteristic type of reddish-brown nodules situated on the nose and contiguous portions of the cheeks. He had also numerous fibromata on the back, and a widespread eruption of small, pale yellow, seed-like tumours all over the back, the little tumours resembling milium, and on close examination appearing to be pierced by lanugo hairs. A histological examination of all classes of tumour showed them to be either pure fibromata or angio-fibromata, though Buschke admits that in the case of the face tumours the excision was so superficial that it is possible that deep sebaceous glands might be present below the point at which the excision took place. The boy was clever at work, and generally showed no physical or mental defect other than the presence of the cutaneous anomaly. A. W. ON THE PATHOGENESIS OF COLLIQUATIVE BULLÆ. KREIBICH. (_Derm. Zeitschr._, Bd. xi, Heft 5, p. 315.) After reviewing shortly the theories at present put forward for the production of colliquative bullæ, Kreibich enters into great detail in the description of his experiments. He finds evidence that in Zoster hystericus there is an acute œdema consisting of fibrinous exudation which enters into the cells and causes their necrosis without separating them from their deep attachments. By irritating the same part three times running with the poison of urtica urens Kreibich was able to produce a colliquative vesicle, since the œdematous process then reached to the papillary body. Similar is the pathogenesis of true herpes zoster and in all probability of hydroa vacciniforme. To sum up the results of the investigation he states that “Colliquative bullæ are found in processes which are allied to urticaria but differ from this in the greater duration of the vascular lesion and by its situation in the papillary body. The colliquation of the epithelium is produced by the action of an exudation rich in fibrin on the epithelial cells, which have suffered in their nutrition but which have maintained their connection with the cutis. The disturbance of nutrition is a combined result of the vascular lesion, the pressure of the exudation, and the resultant anæmia.” A. W. FORMALIN AND ITS ACTION ON FAVUS MOULD. BOGROW AND SCHARKEWITSCH-SCHARSCHINSK. (_Derm. Zeitschr._, Bd. xi, Heft 5, p. 329.)