But what was not visible, nor present in any of the sections, was the
parakeratotic heaping up of scales of the psoriasis lesions.
Exceptionally this may be wanting in cutaneous psoriasis patches, but
its absence is, as a rule, or even always, characteristic, in psoriasis
of mucous membranes. In certain sections, however, the uppermost
epithelial layers, one found, to a depth of three cell layers, were
pressed together to form a dark-coloured narrow band, but having regard
to the smooth contour of the surface this could hardly be looked upon as
a partly developed scale. The pathological characters of any lesions are
to a certain extent altered according to the position in which they
occur. By the word “parakeratosis” is understood, apart from the heaping
up of dry, scaly formations, a condition in which we find the following
changes of the epithelium: parenchymatous œdema, extension of the basal
horny layer, abnormally scanty fat contents of the same, want of
keratohyalin, and abnormally good preservation of the nuclei. Such are,
however, pathological changes of the external epithelium, but normal
conditions of the mucous membranes. Parakeratotic changes of the mucous
membranes of the mouth cannot be considered diagnostic of psoriasis. But
the changes in the papillæ, the infiltration of the upper layer of the
corium, the widening of the blood-vessels, the dilatation of the
lymph-channels, taken in conjunction with the clinical symptoms and the
results of treatment, leave no doubt that the case was one of true
psoriasis vulgaris of the mucous membrane of the mouth. Previously, very
few cases of scaly lesions of the mucous membranes had been described,
and in psoriasis of the skin the extensive and destructive infiltration
seen in these lesions of mucous membranes is unknown.
The ætiology of psoriasis, whether of the skin or mucous membrane, has
been, and is still so hotly discussed, that the translator can but
mention the author’s conclusion that the pathological picture of his
case points anatomically to an inflammatory origin, and ætiologically to
a parasitic origin of psoriasis.
J. L. B.
ERYSIPELAS NEONATORUM GANGRÆNOSUM. E. NOHL. (_Münch. med.
Wochenschr._, September 13th, 1904, p. 1648.)
The child was born on February 29th, and was apparently healthy at
birth; she developed diarrhœa on the fourth day, and redness and
swelling of the genital region on the sixth.
Seen for the first time on March 7th, the labia majora were much
swollen, red and shining and painful. Both thighs presented a firm œdema
and looked blue and marbled. There were frequent motions like pea-soup.
On March 9th the temperature rose above normal for the first time and,
with the exception of the first two evenings, when it sank below normal,
it remained elevated till the child died, reaching 40° C. on March 11th,
and 40·5° C. on March 15th.
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