In the malarial cases the pain is often entirely relieved by quinine or one of its substitutes; on this all are agreed, whether homeopaths or allopaths, or outside of any regular path. It is quite curious how the malarial neuralgias preferably locate in the first division of the fifth. But one word of caution, the mere fact of recurrence or periodicity, more or less regular, does not suffice to establish the diagnosis of malaria, for all neuralgias are apt to be more or less periodic. You must get definite symptoms of chill or fever before you can be sure. Once sure, the treatment is plain: efficient doses of the antiperiodic. When we come to the syphilitic cases we enter more debateable territory. The pains about the head, especially the teeth, are sometimes not due to the disease, but to the means taken to combat it. I do not intend here to take up the question of the treatment of the secondary stage, except to enter my protest as to the harm done, especially to the teeth, by routine overdosing with mercury. Fortunately this abuse of a most valuable remedy is much lessening. In the third stage of syphilis you sometimes get most remarkable pain manifestations, and I had one in my practice that I cannot refrain from quoting. A gentleman, aged between 40 and 45, had suffered for years from recurrent attacks of pain of great severity. When I saw him the pain, although more or less present constantly, had very marked exacerbations every afternoon. It was located in the great occipital nerves, especially on right side. Had formerly had considerable pain in distribution of right inferior dental nerve. His occupation was sedentary and involved considerable mental application. He stated on questioning that some eighteen years before he contracted syphilis. From this he believed himself cured. He had subsequently married, but had no children. Having suffered for six or eight years from these attacks of pain at varying intervals, he had consulted numerous physicians with only temporary benefit. He was very despondent; his sufferings were very intense, and only the most powerful anodynes gave relief. After some investigation, I made up my mind that the syphilitic dyscrasia lay at the bottom of his suffering. I therefore began specific treatment with iodide of potash. Prof. Seguin, who saw him in consultation, concurred in both diagnosis and the line of treatment. He suggested pushing the iodide until its therapeutic limit was reached. This was done; but it was not until the enormous dose of one-half ounce thrice daily was reached that the pain yielded. During one week this patient took over one pound of iodide of potash. A course of mercury in small doses completed the cure. Two years have now elapsed, and the patient has had no recurrence of pain.