In this stage all symptoms of a pronounced typhoid condition supervene. Tongue becomes parched and black. Sordes cover the teeth. Gradually a somnolent condition and low muttering delirium supervene. In some cases the delirium is violent and furious, while in others it culminates in complete stupor and coma. Picking of the bed-clothes, and subsultus tendinum are common, and the urine and fæces are passed involuntarily. The pupils are dilated. The skin is bathed with profuse perspiration. The pulse is dichrotic and compressible, and gradually becomes anachrotic and intermittent till it finally fails. The area of cardiac dullness is increased and pain in the cardiac region is complained of. Heart begins to fail rapidly. The usual complications of this stage are—(1) meningites; (2) hæmorrhages; (3) severe gastric disturbance, such as vomiting, diarrhœa, hiccough. As a rule, constipation is found during the course of an attack, but diarrhœa, even severe, may appear. There may be pain in the abdomen. Bladder may be distended and a catheter may be necessary to evacuate it. Cystitics often develop. Œdema of the lungs, pleurisy and pneumonia may also complicate a case. Hæmaturia, hæmoptysis and hæmatemesis may be seen. Bronchitis and hypostatic inflammation may occur. The urine always shows presence of albumen. Death may take place from cardiac failure or from any of the above complications. Death may take place within three or four days, though in some virulent cases the patient dies within twenty-four hours. If the primary collapse is tided over, there is great chance of recovery, still deaths often occur of complications several days after the attack. In mild cases the second stage is not so severe, and temperature may fall by lysis or crisis—the latter being rare.