It is an ancient disease mentioned in Hindoo and Christian Scriptures. Long before the Christian era it prevailed in Greece, attacking the town of Piræus, where it raged for two years. Egypt, Syria, Constantinople and Rome were visited by the plague. In Constantinople the outbreak was once so furious that during three months from 5,000 to 10,000 deaths occurred daily. The first historical allusion to plague was made by Rufus, a physician who lived in the reign of Trajan (A.D. 98-117), and who mentions of glandular swellings. In 1347, plague appeared in almost all countries in Europe, where Hecker believes, 25 millions of persons perished. Ireland was visited by plague three hundred years after its invasion by Patrolan, and it is said that 9,000 people died in a week and were buried at Tallagh near Dublin—a name which means the burial place of the plague-stricken. Plague visited England frequently, and no fewer than eighteen epidemics are said to have occurred before the great plague of 1665. In 1720, 40,000 out of a population of 90,000 died at Marseilles. In 1751, 150,000 died of plague in Constantinople. In 1799 the French Army in Syria was devastated by plague. 6,000 persons died in Malta in 1813. In 1834-35, 14,888 persons died in Alexandria out of a population of 42,000. In 1876 there was an outbreak of the disease at Kumaon in Northern India, where it prevailed several times during the present century, and where it is known as the _Maha-Mari_. It is also said that it prevailed in 1815 on the Island of Kutch, and lasted till 1821 in Kutch and Sindh. It also occurred between the years 1828 and 1838 in Jhansi, Bareilly, Pali and Jodhpore. In China the plague has been present for a long time in an epidemic form. In 1894 60,000 persons died at Canton. From Canton it spread to Hongkong and to Amoy. In 1895, it visited many places in Southern China. In 1896, it was present at Hongkong. Some people think that the disease has come to Bombay probably from Singapore. There was an epidemic at Merv when the Bombay outbreak appeared, others, however, think that the epidemic at Merv was not that of plague and that the disease has come from Hongkong. _THE LONDON EPIDEMIC OF 1665._ The following graphic and interesting account of the great London Epidemic of 1665 is taken from Sir William Guy’s book on “Public Health.” “I now turn for a more exact account of the plague of 1665 to the work of Dr. Nathaniel Hodges, a Fellow of the College of Physicians, resident in the City, and, as his book shows, in active practice among the victims of the disease. “Dr. Munk, in his roll of the Royal College of Physicians of London, says that he ‘acquired a great name among the citizens of London; that he remained at his post and continued in unremitting attendance on the sick,’ and that ‘during the latter part of his life he received a regular stipend from the City of London for the performance of his charitable office.’