In these cases the poisonous substance is usually a compound of paraphenylene-diamine, the same poisonous substance that causes irritation of the scalps of those who attempt to dye gray hair black. Many foreign nations have introduced laws to prevent the use of this substance in hair dyes and to regulate the fur-dying industry. Similar laws have been passed in some of our states, but there is as yet no nation-wide regulation regarding the use of this substance. _Investigate Cases._--Not all persons are equally sensitive to this dye. Some may wear furs dyed in this manner without symptoms, but those who are sensitive develop severe reactions. Several investigative committees are attempting to secure a record of all the cases of this type that occur. If anyone knows of such an instance, the report may be sent to the Committee on Dye Poisoning of the American Medical Association, 535 N. Dearborn Street, Chicago. MOST MOLES HARMLESS, BUT WATCH BLACK ONES! It has been estimated that there are five moles on an average on every person in the city of Chicago. If all of these were to be removed, it would require more than 15,000,000 separate surgical operations. The history of moles would be an extremely interesting topic, since they were long regarded as of great significance--sometimes considered the work of evil spirits; sometimes thought to be due to the influence of the moon or the stars, and occasionally thought to be of importance in determining configuration of the body. _Superstition._--Charts of moles were prepared so that one might tell by observation of those that were visible where to expect others that might be invisible. Needless to say, all of this was superstitious and without the slightest scientific importance. As long as a mole does not disfigure the appearance, it is best disregarded, unless under certain circumstances it becomes irritated and subject to the unusually rapid growth that is characteristic of cancer. If a mole is extremely brown or black, it has in it an unusual amount of a pigment called melanin, which is responsible for giving the color to the hair, the eyes, and the deeper layers of skin. Somehow, the presence of this substance seems to be associated with dangerous possibilities, so that a severe injury or irritation of a deeply pigmented mole may cause it to suddenly develop rapid growth. _Watch Black Ones._--The most dangerous moles are those that are jet black. If these are situated where they are constantly rubbed or irritated by collars, garters, shoes or other garments, they should be most carefully watched. The danger signs have been listed by some doctors as: (1) a gradual increase in the size of the mole; (2) deepening or spreading of the color; (3) ulceration or infection; (4) pain or soreness in the mole.