[Footnote 46: Byrd Manuscripts, I., 180. The reader will find a convenient map for the southern region in Roosevelt, Winning of the West, I.] [Footnote 47: Spottswood's Letters, I., 40; II., 149, 150.] [Footnote 48: Ramsay, 64. Note the bearing of this route on the Holston settlement.] [Footnote 49: Georgia Historical Collections, I., 180; II., 123-7.] [Footnote 50: Spottswood. II., 331, for example.] [Footnote 51: Ramsay, 65.] [Footnote 52: Boone, Life and Adventures.] [Footnote 53: Observations on the North American Land Co., pp. xv., 144, London, 1796.] [Footnote 54: Margry, VI.] [Footnote 55: Allen, Lewis and Clarke Expedition, I., ix.; _vide post_, pp. 70-71.] [Footnote 56: _Vide post_, p. 71.] [Footnote 57: _Century Magazine_, XLI., 759.] [Footnote 58: Jessie Benton Fremont in _Century Magazine_, XLI., 766-7.] [Footnote 59: _Century Magazine_, XLI., p. 759; _vide post_, p. 74.] [Footnote 60: Parkman's works, particularly Old Regime, make any discussion of the importance of the fur trade to Canada proper unnecessary. La Hontan says: "For you must know that Canada subsists only upon the trade of skins or furs, three-fourths of which come from the people that live around the Great Lakes." La Hontan, I., 53, London, 1703.] NORTHWESTERN RIVER SYSTEMS IN THEIR RELATION TO THE FUR TRADE. The importance of physical conditions is nowhere more manifest than in the exploration of the Northwest, and we cannot properly appreciate Wisconsin's relation to the history of the time without first considering her situation as regards the lake and river systems of North America.