The plan of treatment which I have found most successful, consisted in varying the following means according to circumstances. Within the first four hours after an attack, bleeding will generally be necessary; but when prostration has ensued and when the surface is covered with cold sweat, leeches to the epigastric region, or cupping followed by warm fomentations or mustard plaster or blister, together with frictions and heat to the extremities, will afford the greatest and most speedy relief. Notwithstanding the various and multiplied articles of the materia medica which have been recommended, as opium, calomel, oxide of bismuth, cajuput oil, spirits, &c. to allay vomiting and purging and calm spasms, I must give my decided preference to dermoid applications, which invite the blood from the heart, lungs, liver, stomach, &c. the congestion of which produces these symptoms. I do not deny that there are cases which can be, and are relieved by medicines; but, since we possess no remedy which can drive the blood from the centre to the surface--since all internal medicines are apt to excite vomiting, one of the most painful, distressing and fatal symptoms of cholera--and moreover, since we possess means which can be easily managed and varied to suit circumstances, and whose action is plain and evident to the senses--I cannot forsake them to launch upon the sea of experiment and conjecture, in the treatment of this rapid disease. The language of those who advocate the administration of internal remedies, is to give so much of a mixture or so many pills, and if they produce _vomiting_, repeat the dose; but if a cure is to be effected by relieving the symptoms, why give those medicines which excite or aggravate them? An infusion of peppermint, or the oil or essence of this plant, with a few drops of laudanum, in a little warm brandy and water, is what I have found best adapted for internal use; and even this should be prohibited when it produces vomiting. This symptom is often so distressing and so easily excited, that the stomach will reject whatever is presented to it. In such cases, I rely upon the horizontal position, perfect rest, and heat and frictions to the abdomen and extremities, without administering any thing internally. The warm bath I have known to be of great service, but the time necessary to prepare it and the exposure of the body to the air, are serious objections to its general employment. The same will not hold good in relation to the vapour bath, where the patient can be kept continually warm. Excessive thirst is best relieved by cold gum water, or by a piece of ice dissolved in the mouth.