[Sidenote: The Scourge of 1849] Cholera was approaching the shores of England. The alarm of the people was intense. The enormous devastations of that pestilence on its first and only previous visit to that country, in 1832, were vividly recalled by the elder people. The only known preventive measures were “flight, fasting, and prayer.” As the pestilence was believed to be a “visitation of God” on account of the sins of the people, the clergy petitioned the Prime Minister to proclaim a day of “fasting and prayer,” with many expressions of sorrow at the prevailing national vices which had finally provoked the wrath of the Almighty. The Prime Minister replied in substance as follows: “Do works meet for repentance. First make your homes and their surroundings clean and wholesome; then you may with propriety ask Almighty God to bless your efforts at protection against the approaching epidemic.” This response of the highest official of the Kingdom to the usually humble and devout petition of the clergy, when the people were threatened with an epidemic, was received with profound astonishment by the religious classes, with ridicule by the masses of the people, but with commendation by sanitarians. The popular agitation was great. The clergy protested with solemn asseverations their belief that pestilences were always indications that national sins had become intolerable to the Almighty, and only fastings and prayers could appease His wrath. The people at large gave no heed either to the clergy’s admonition to fast and pray, or to the Prime Minister’s advice to clean their homes and their surroundings; but, with their usual disregard of the domestic diseases with which they were constantly familiar, gave no thought to approaching danger. But the sanitarians very earnestly urged the people of their respective localities to act upon the advice of the Prime Minister, assuring them that cholera was a disease which prevailed more generally and severely in localities and homes where there was the greatest amount of “filth.” The epidemic of 1849 came and went with its apparent usual great disturbances of the people. “Flight” and “fasting and prayers” had their natural results, the former being effectual when undertaken in time, and the latter without sensible influence over the mortuary records. [Sidenote: Can Diseases Be Prevented?] Then the net results of this visitation of cholera were officially determined by the Registrar-General, one fact attracted wide attention and created a profound and lasting impression on the minds of the common people. A town in the interior of England reported no case of cholera, though the epidemic had prevailed with great virulence in the communities surrounding it.