That hence results such failure of guidance by pleasures and pains as is daily exhibited, we discover on observing in what parts of conduct the failure is most conspicuous. As above shown, the pleasurable and painful sensations are fairly well adjusted to the peremptory physical requirements: the benefits of conforming to the sensations which prompt us in respect of nutrition, respiration, maintenance of temperature, etc., immensely exceed the incidental evils, and such misadjustments as occur may be ascribed to the change from the outdoor life of the primitive man to the indoor life which the civilized man is often compelled to lead. It is the emotional pleasures and pains which are in so considerable a degree out of adjustment to the needs of life as carried on in society, and it is of these that the readjustment is made in the way above shown, so tardy because so difficult. From the biological point of view, then, we see that the connections between pleasure and beneficial action and between pain and detrimental action, which arose when sentient existence began, and have continued among animate creatures up to man, are generally displayed in him also throughout the lower and more completely organized part of his nature; and must be more and more fully displayed throughout the higher part of his nature, as fast as his adaptation to the conditions of social life increases. § 36. Biology has a further judgment to pass on the relations of pleasures and pains to welfare. Beyond the connections between acts beneficial to the organism and the pleasures accompanying performance of them, and between acts detrimental to the organism and the pains causing desistance from them, there are connections between pleasure in general and physiological exaltation, and between pain in general and physiological depression. Every pleasure increases vitality; every pain decreases vitality. Every pleasure raises the tide of life; every pain lowers the tide of life. Let us consider, first, the pains. By the general mischiefs that result from submission to pains, I do not mean those arising from the diffused effects of local organic lesions, such as follow an aneurism caused by intense effort spite of protesting sensations, or such as follow the varicose veins brought on by continued disregard of fatigue in the legs, or such as follow the atrophy set up in muscles that are persistently exerted when extremely weary; but I mean the general mischiefs caused by that constitutional disturbance which pain forthwith sets up. These are conspicuous when the pains are acute, whether they be sensational or emotional.