There is much to indicate that Strong’s cholera autolysate is of value prophylactically. In this cholera cultures are killed at 60°C. The killed culture is then allowed to digest itself in the incubator at 37°C. for three or four days (peptonization). The preparation is then filtered and from 2 to 5 cc. of the filtrate is injected. =Treatment.=—Many of the older authorities recommended the use of various astringent medications for the checking of suspicious diarrhoeas and most of these prescriptions contained opium in some form, such as lead and opium pills or aromatic sulphuric acid and laudanum. In view of the fact that for the infection of animals Koch had to employ opium for checking peristalsis in addition to neutralization of gastric juice it would seem very undesirable to use opium by mouth. Calomel in divided doses and continued over one or two days, but not exceeding 7 or 8 grains, has been recommended. At present the treatment which is thought to give the best results is the permanganate one proposed by Rogers. In this the patient is given calcium permanganate water ad libitum and 2-grain pills of potassium permanganate every half hour until the stools become more faecal in character. These pills are made up with vaseline and coated with a mixture of a 1 part salol and 5 parts of sandarach varnish. Reports as to the use of kaolin in treatment and as a prophylactic have been favorable. The suspension in water is given as a drink and as an enema. Rogers has recently been administering 1/100 of a grain of atropine sulphate morning and evening. His statistics would indicate a reduction in mortality of about one-half. Cases treated with atropine also rarely show collapse. Injections of adrenalin solutions have been recommended. A great objection to any form of oral medication is the tendency to vomiting. This can in a measure be controlled by cracked ice or by a small hypodermic of morphia. The latter drug also relieves the very painful cramps. One danger which must always be borne in mind in giving more than one dose of any drug subcutaneously is that with the slowing or cessation of circulation, coming on with the algid state, we have no absorption but, when the stage of reaction sets in and the drug, whether morphine or toxic stimulant, begins to be taken up, there may ensue a fatal poisoning. However the views of authorities may conflict as to special forms of treatment, there is universal acceptance of the employment of intravenous injections of fluid to combat collapse. Normal saline is the fluid usually used, but Rogers recommends his hypertonic solution which consists of 120 grains of sodium chloride, 6 grains of potassium chloride and 4 grains of calcium chloride to the pint of water. In the Philippines the normal saline seemed to answer as well as the hypertonic solution.