In the following year, vaccine inoculation began to spread, the practice being taken up by many of Jenner's friends, including several who were not in the medical profession. But, like inoculation for the small-pox, when introduced by Lady Mary Wortley Montagu,--like all innovations on established practices, indeed,--vaccination received for many years after its introduction the most violent opposition. Just as inoculation for small-pox had been denounced from the pulpit and in medical treatises as a "diabolical operation" and a wicked interference with the designs of Providence, so did a certain Dr. Squirrel denounce vaccination as an attempt to change "the established laws of nature." The most absurd stories were circulated of the effects alleged to have followed vaccination. "A lady," it is stated by Mr. Bettany, "complained that since her daughter had been vaccinated she coughed like a cow, and had grown hairy all over her body; and in one country district it was stated that vaccination had been discontinued there, because those who had been inoculated in that manner bellowed like bulls." There were even doctors who pretended to detect resemblances to bovine visages in the countenances of children, produced, as they did not hesitate to declare, by vaccination! Self-interest may have had as much to do as prejudice in prompting the opposition of the profession. Many practitioners derived a considerable portion of their income from fees for inoculation for small-pox. Sutton, as we have seen, charged five guineas for the operation, and advertised himself in many provincial newspapers; and the income of Dr. Woodville, at one time physician to the Small-Pox Hospital, is said to have sunk in one year from a thousand pounds to a hundred on his adopting the practice of vaccination. Notwithstanding the prejudice and interested antagonism to which the new practice was exposed, it continued to make way. The Rev. Dr. Booker, of Dudley, gave the following striking testimony to its beneficial effects:--"I have, previous to the knowledge of vaccine inoculation, frequently buried, day after day, several (and once as many as eight) victims of the small-pox. But since the parish has been blessed with this invaluable boon of Divine Providence (cow pox), introduced among us nearly four years ago, only two victims have fallen a prey to the above ravaging disorder (small pox). In the surrounding villages, like an insatiable Moloch, it has lately been devouring vast numbers, where obstinacy and prejudice have precluded the Jennerian protective blessing."