12 P. M. The thirst strangely increased. He had drunk or spilled full three quarts of water. There was a peculiar eagerness in his manner. He plunged his nose to the very bottom of his pan, and then snapped at the bubbles which he raised. No spasm followed the drinking. He took two or three pieces from my hand, but immediately dropped them from want of power to hold them. Yet he was able for a moment suddenly to close his jaws. When not drinking he was barking with a harsh sound, and frequently started suddenly, watching, and catching at some imaginary object. 24th, A. M. He was more furious, yet weaker. The thirst was insatiable. He was otherwise diligently employed in shattering and tearing everything within his reach. He died about three o'clock. It is impossible to say what was the origin of this disease in him. It is not connected with any degree or variation of temperature, or any particular state of the atmosphere. It is certainly more frequent in the summer or the beginning of autumn than in the winter or spring, because it is a highly nervous and febrile disease, and the degree of fever, and irritability, and ferocity, and consequent mischief are augmented by increase of temperature. In the great majority of cases, the inoculation can be distinctly proved. In very few can the possibility be denied. The injury is inflicted in an instant. There is no contest, and before the injured party can prepare to retaliate, the rabid dog is far away. It can easily be believed that when a favourite dog has, but for a moment, lagged behind, he may be bitten without the owner's knowledge or suspicion. A spaniel belonging to a lady became rabid. The dog was her companion in her grounds at her country residence, and it was rarely out of her sight except for a few minutes in the morning, when the servant took it out. She was not conscious of its having been bitten, and the servant stoutly denied it. The animal died. A few weeks afterwards the footman was taken ill. He was hydrophobous. In one of his intervals of comparative quietude he confessed that, one morning, his charge had been attacked and rolled over by another dog; that there was no appearance of its having been bitten, but that it had been made sadly dirty, and he had washed it before he suffered it again to go into the drawing-room. The dog that attacked it must have been rabid, and some of his saliva must have remained about the coat of the spaniel, by which the servant was fatally inoculated.