Another case of this fearful disease must not be passed over. A dog that had been docile and attached to his master and mistress, was missing one morning, and came home in the evening almost covered with dirt. He slunk to his basket, and would pay no attention to any one. His owners thought it rather strange, and I was sent for in the morning. He was lying on the lap of his mistress, but was frequently shifting his posture, and every now and then he started, as if he heard some strange sound. I immediately told them what was the matter, and besought them to place him in another and secure room. He had been licking both their hands. I was compelled to tell them at once what was the nature of the case, and besought them to send at once for their surgeon. They were perfectly angry at my nonsense, as they called it, and I took my leave, but went immediately to their medical man, and told him what was the real state of the case. He called, as it were accidentally, a little while afterwards, and I was not far behind him. The surgeon did his duty, and they escaped. In May, 1820, I attended on a bitch at Pimlico. She had snapped at the owner, bitten the man-servant and several dogs, was eagerly watching imaginary objects, and had the peculiar rabid howl. I offered her water. She started back with a strange expression of horror, and fell into violent convulsions that lasted about a minute. This was repeated a little while afterwards, and with the same result. She was destroyed. The horrible spasms of the human being at the sight of, or the attempt to swallow, fluids occur sufficiently often to prove the identity of the disease in the biped and the quadruped; but not in one in fifty cases is there, in the dog, the slightest reluctance to liquids, or difficulty in swallowing them. In almost every case in which the dog utters any sound during the disease, there is a manifest change of voice. In the dog labouring under ferocious madness, it is perfectly characteristic. There is no other sound that it resembles. The animal is generally standing, or occasionally sitting, when the singular sound is heard. The muzzle is always elevated. The commencement is that of a perfect bark, ending abruptly and very singularly, in a howl, a fifth, sixth, or eighth higher than at the commencement. Dogs are often enough heard howling, but in this case it is the perfect bark, and the perfect howl rapidly succeeding to the bark. Every sound uttered by the rabid dog is more or less changed. The huntsman, who knows the voice of every dog in his pack, occasionally hears a strange challenge. He immediately finds out that dog, and puts him, as quickly as possible, under confinement. Two or three days may pass over, and there is not another suspicious circumstance about the animal; still he keeps him under quarantine, for long experience has taught him to listen to that warning. At length the disease is manifest in its most fearful form.