Kaye’s treatment of the Sweating Sickness is according to the mild old English plan, which is very judiciously and perspicuously laid down. He kept himself, on the whole, free from the influence of the schools in this instance, and the only remedy which he approved in case of necessity, was a harmless and very favourite preparation of pearls and odoriferous substances, which was called Manus Christi[802], or, in Germany, sugar of pearls. It had its origin in the fifteenth century, and was the invention of _Guainerus_[803], and there were various receipts for compounding it[804]. He also sometimes prescribed, at the commencement of the attack[805], bole or terra sigillata, for how could a physician of the sixteenth century doubt the antipoisonous effect of this overrated remedy? Restlessness in the patient, debility, a too thick skin, and thick blood, are set forth by him as the chief impediments to the critical sweat, and in order to remove them, he sets to work with great and laudable caution, ordering, according to circumstances, even mulled wine and greater warmth. Sometimes, too, he could not refrain from employing Theriac and Mithridate, but he did not use these remedies to any great extent. For dropsical and rheumatic patients who became the subjects of the Sweating Sickness, he prescribed a beverage of Guaiacum; he also recommended as a sudorific, the China root, which was at that time much in use. When the perspiration broke out, he positively prohibited the urging it beyond the proper point; all medicines were thence laid aside, and he trusted to aromatic vinegar and gentle succussion alone for keeping off the lethargy, without considering, with _Damianus_, that more severe measures were essential[806].