The production of deep sleep and the usual accompanying abolition of pain have been subjects which have ever appeared, in some form, in myth or fable, and to which poets of all times have alluded, usually with poetic license. One of the most popular of these fables connects the famous oracle of Apollo, at Delphi, whence proceeded mysterious utterances and inchoate sounds, with convulsions, delirium and insensibility upon the part of those who approached it. To what extent there is a basis of fact in this tradition can never be explained, but it is not improbable from what we now know of hypnotic influence. From all time it has been known that many different plants and herbs contained principles which were narcotic, stupefying or intoxicating. These properties have especially been ascribed to the juices of the poppy, the deadly nightshade, henbane, the Indian hemp and the mandrágora, which for us now is the true mandrake, whose juice has long been known as possessing soporific influence. Ulysses and his companions succumbed to the influence of _Nepenthe_; and, nineteen hundred years ago, when crucifixion was a common punishment of malefactors, it was customary to assuage their last hours upon the cross by a draught of vinegar with gall or myrrh, which had real or supposititious narcotic properties. Even the prophet Amos, seven hundred years before the time of Christ, spoke of such a mixture as this as "the wine of the condemned," for he says, in rehearsing the iniquities of Israel by which they had incurred the anger of the Almighty: "And they lay themselves down upon the clothes laid to pledge by every altar, and they drink the wine of the condemned in the house of their God," (Chap. II, verse 8), meaning thereby undoubtedly that these people, in their completely demoralized condition, drank the soporific draught kept for criminals. Herodotus mentions a habit of the Scythians, who employed a vapor generated from the seed of the hemp for the purpose of producing an intoxication by inhalation. Narcotic lotions were also used for bathing the people about to be operated upon. Pliny, who perished at the destruction of Herculaneum, A. D. 79, testified to the soporific power of the preparations made from mandrágora upon the faculties of those who drank it. He says: "It is drunk against serpents and before cuttings and puncturings, lest they should be felt." He also describes the indifference to pain produced by drinking a vinous infusion of the seeds of eruca, called by us the rocket, upon criminals about to undergo punishment. Dioscorides relates of mandrágora that "some boil down the roots in wine to a third part, and preserve the juice thus procured, and give one cyathus of this to cause the insensibility of those who are about to be cut or cauterized." One of his later commentators also states that wine in which mandrágora roots have been steeped "does bring on sleep and appease pain, so that it is given to those who are to be cut, sawed or