burnt in any parts of their body, that they may not perceive pain." Apuleius, about a century later than Pliny, advised the use of the same preparation. The Chinese, in the earlier part of the century, gave patients preparations of hemp, by which they became completely insensible and were operated upon in many ways. This hemp is the cannabis Indica which furnishes the _Hasheesh_ of the Orient and the intoxicating and deliriating _Bhang_, about which travelers in the East used to write so much. In Barbara, for instance, it was always taken, if possible, by criminals condemned to suffer mutilation or death. According to the testimony of medieval writers, knowledge of these narcotic drugs was practically applied during the last of the Crusades, the probability being that the agent principally employed was this same hasheesh. Hugo di Lucca gave a complete formula for the preparation of the mixture, with which a sponge was to be saturated, dried, and then, when wanted, was to be soaked in warm water, and afterward applied to the nostrils, until he who was to be operated upon had fallen asleep; after which he was aroused with the vapor of vinegar. Strangely enough, the numerous means of attaining insensibility, then more or less known to the common people, and especially to criminals and executioners, do not appear to have found favor for use during operations. Whether this was due to unpleasant after-effects, or from what reason, we are not informed. Only one or two surgical writers beside Guy de Chauliac (1498) refer in their works to agents for relief of pain, and then almost always to their unpleasant effects, the danger of producing asphyxiation, and the like. Ambrose Paré wrote that preparations of mandrágora were formerly used to avert pain. In 1579, an English surgeon, Bulleyn, affirmed that it was possible to put the patient into an anaesthetic state during the operation of lithotomy, but spoke of it as a "terrible dream." One Meisner spoke of a secret remedy used by Weiss, about the end of the XVII Century, upon Augustus II., king of Poland, who produced therewith such perfect insensibility to pain that an amputation of the royal foot was made without suffering, even without royal consent. The advice which the Friar gave Juliet regarding the distilled liquor which she was to drink, and which should presently throw her into a cold and drowsy humor, although a poetic generality, is Shakespeare's recognition of a popular belief. Middleton, a tragic writer of Shakespeare's day, in his tragedy known as "Women beware Women," refers in the following terms to anesthesia in surgery: "I'll imitate the pities of old surgeons To this lost limb, who, ere they show their art, Cast one asleep; then cut the diseased part."