Now, let us for the first time make use of our biogenetic law; and directly apply this fundamental law of evolution to the human ovum. We reach a very simple, but very important, conclusion. _ From_ _the fact that the human ovum and that of all other animals consists of a single cell, it follows immediately, according to the biogenetic law, that all the animals, including man, descend from a unicellular organism._ If our biogenetic law is true, if the embryonic development is a summary or condensed recapitulation of the stem-history—and there can be no doubt about it—we are bound to conclude, from the fact that all the ova are at first simple cells, that all the multicellular organisms originally sprang from a unicellular being. And as the original ovum in man and all the other animals has the same simple and indefinite appearance, we may assume with some probability that this unicellular stem-form was the common ancestor of the whole animal world, including man. However, this last hypothesis does not seem to me as inevitable and as absolutely certain as our first conclusion. Fig.15 A fertilised ovum from the oviduct of a hen Fig. 15—A fertilised ovum from the oviduct of a hen. The yellow yelk (_c_) consists of several concentric layers (_d_), and is enclosed in a thin yelk-membrane (_a_). The nucleus or germinal vesicle is seen above in the cicatrix or “tread” (_b_). From that point the white yelk penetrates to the central yelk-cavity (_d′_). The two kinds of yelk do not differ very much. This inference from the unicellular embryonic form to the unicellular ancestor is so simple, but so important, that we cannot sufficiently emphasise it. We must, therefore, turn next to the question whether there are to-day any unicellular organisms, from the features of which we may draw some approximate conclusion as to the unicellular ancestors of the multicellular organisms. The answer is: Most certainly there are. There are assuredly still unicellular organisms which are, in their whole nature, really nothing more than permanent ova. There are independent unicellular organisms of the simplest character which develop no further, but reproduce themselves as such, without any further growth. We know to-day of a great number of these little beings, such as the gregarinæ, flagellata, acineta, infusoria, etc. However, there is one of them that has an especial interest for us, because it at once suggests itself when we raise our question, and it must be regarded as the unicellular being that approaches nearest to the real ancestral form. This organism is the _Amœba._ Fig.16 A creeping amœba. Fig. 16—A creeping amœba (highly magnified). The whole organism is a simple naked cell, and moves about by means of the changing arms which it thrusts out of and withdraws into its protoplasmic body. Inside it is the roundish nucleus with its nucleolus.