As long as we are so far from an understanding of life no theory of regeneration can be anything more than a 'portmanteau theory,' as Delage once expressed himself in relation to the whole theory of inheritance, a theory which is like a portmanteau in that one can only take out of it what has previously been put in. If we wish to explain the renewal of the aboral band of cilia in a Stentor, we first pack our trunk, in this case the nucleus of the Infusorian, with the determinants of the ciliated region, and then think of these as being liberated by the stimulus of wounding, and being brought to and arranged in the proper place by unknown forces to reconstruct the ciliary region in some unknown way. No one could be more clearly aware than I am that this is not an exhaustive causal explanation of the process itself. Nevertheless, it is not quite without value, inasmuch as it allows us at least to bring the facts together in rational order--in this case the dependence of the faculty of regeneration on the presence of nuclear substance--under a formula which we can use provisionally, that is, with which we can raise new questions. As soon as we ascend higher in the series of organisms the theory gains a greater value, for, while we leave altogether out of account any answer to the ultimate question, and thus renounce for the present the attempt to find out how the determinants set to work to call to life the parts which they control, we are brought face to face with other, in a sense, preliminary questions which we _can_ solve, and the solution of which seems to me at least not entirely without value. The first of these questions runs thus: Is the power of regeneration a fundamental, primary character of every living being in the sense that it is present everywhere in equal strength, independently of external conditions, and thus is an inevitable outcome of the primary characters of the living substance? Or is it, though primaeval in its beginnings, a phenomenon of adaptation, which depends on a special mechanism, and does not occur everywhere in equal extent and potency? We have already become acquainted with some facts which must incline us to the latter view. The globular Alga-colonies of _Volvox_ (Fig. 63) consist of two kinds of cells, of which only one kind, the reproductive cells, possess the power of reproducing the whole, the others, the flagellate, or, as we called them, somatic cells, being only able to produce their like, but never the whole. New investigations which have been carried out by Dr. Otto Hübner in my Institute have placed these facts beyond doubt. We may conclude that, in this case, a disintegration of the germ-plasm has taken place during ontogeny, by means of differential cell-division, so that only the reproductive cells receive the complete germ-plasm, while the somatic cells receive only the determinants necessary to their own specific differentiation, the somatic determinants.