But the departure of Margaret from Flanders in August 1501 for her marriage with the Duke of Savoy put an end for a time to her pretensions to take charge of her brother's children; and when she returned as a young widow early in 1505, the issue between Ferdinand and his undutiful son-in-law was joined, for Isabella the Catholic was dead, and Philip in right of his wife was arrogantly claiming, not only the crown of Castile, but the entire control of its policy against the wish of the great Queen just dead, whose last hours were embittered by the dread that her beloved, her sacred, Castile, would be ruled by a foreigner of doubtful orthodoxy. Philip was abetted in his revolt against Ferdinand by the Castilian officers attached to him who were jealous of Aragon, Don Juan Manuel, the principal Spanish diplomatist of his time, being their leader and Philip's prime adviser. As soon as Margaret arrived in her brother's Court both factions tried to gain her. 'My lady,' Don Juan Manuel is represented to have said to her on one occasion (June 1505), 'I shall be able to serve you quite as effectively as Antonio de Fonseca when I am in Castile and Treasurer-General'; and at this time, when Philip and his friends were anticipating the rich booty they would gain in Castile, whither they were bound to take possession of mad Joanna's inheritance, Margaret was beset with offers of reward if she would throw in her influence against King Ferdinand. It is abundantly clear that she grieved at the unhappy state of affairs. Ferdinand and his wife had been good to her in Spain, and easy-going as she may have been, she must have seen her brother's unworthiness and his bad treatment of Joanna; and yet it was neither prudent nor natural that she should oppose Philip violently. Fuensalida saw her in Bois le Duc in June 1505, whilst she was on her way to Bourg, and discussed matters with her. 'She told me that she had talked to her brother, and had asked him whether he would allow her to mediate between him and your Highness (Ferdinand), and he had answered, "No, you are still marriageable, and so is he, and I will not have any such third person interposing between us." She told me that her father and brother have made her swear that she will not entertain any marriage without their consent. She really believes that those who are around her brother have turned his head, and will not let him make terms with your Highness.... She bids me tell your Highness that she will continue to be as obedient a daughter to you as she was when she was with you in Spain; and that she is going to her own home now for no other reason than that she cannot bear to see in silence the things that are going on, whereas if she spoke of them or protested against them, evil would come of it. She prefers, therefore, to go away, so that she may not witness them personally; for she sees quite plainly that the destruction of her brother's and her father's house will ensue.