1427. Epidemic. Widespread in France and the continent of Europe. Name given to the disease, Ladendo. Symptoms, cough, insomnia, renal pains, anorexia, rigors constantly. The greeting everywhere on meeting friends was “Have you had Ladendo?” *1510. PANDEMIC I. All over Europe. First accurate description given of its prevalence in the British Isles. Mild in type. Names given in France, Cephale Catarrhale and Coqueluche; in Britain Coccoluche. (Authority, T. Thompson.) 1557. Came from Constantinople. Very fatal. Spread to U. S. A. Ravaged Paris in July and August, Spain in August, England in September, Holland in October. Distinctive symptoms, “tightness and dreadful oppression over the chest, as if bound with red hot chains; the same sensations over the abdomen and stomach.” (Authorities, Thompson, Herman.) 1562. Mild Epidemic. 1563. Mild Epidemic. 1580 PANDEMIC II. Started on the north coast of Africa in Algiers and Morocco, in May, also in the Island of Malta. Spread to the U. S. A. (Authority, Fonseca of Madrid.) England ravaged August, September, October, November. Rome, 9,000 persons died. Barcelona, Cadiz, Cordova, Seville, Madrid and other Spanish cities are said to have been depopulated. The Spanish Physicians bled their patients, this venesection is said to have been very fatal; those who were not bled, most lived. Thomas Short, London, 1587, states on page 9, “All had the Coccoluche; few died except those who were bled or had unsound Viscera.” Anna, wife of Philip I. of Spain, died of the disease. Pope Gregory XIII. was given up for death, but recovered. Epidemics in 1591, 1593, 1597, 1626. 1647 Noah Webster states, “For the first time Influenza is mentioned in the history of U. S. America, but it must not be concluded in the absence of earlier records, that the disease never occurred in the U. S. A.” Webster also cites from Hubbard, “the disease swept the Southern States and the plantations.” The West Indies were ravaged and had an extensive morbidity; on each of the Islands of Barbadoes and St. Kitts there were 5,000 to 6,000 cases. 1658 Epidemic in Europe, started the end of April. Thomas Wills, M.D. of Oxford, says, “the cause of the disease was a Blast from the Stars.” 1675 Epidemic, ravaged Germany. 1688 Epidemic, began in May. Europe swept. Great mortality in Britain. 1693 Epidemic. Europe. 1709 Epidemic in Europe. France, Germany and Italy chiefly affected. 1712