In mental disease, of the type known as Maniac Depressive insanity, there is a curious oscillation of self-love and self-admiration. This disease is cyclic, in that two opposing groups of symptoms tend to appear and displace each other. In the manic, or excited state, there is greatly heightened activity with correspondingly heightened feeling of power. Self-love and admiration reach absurd levels: one is the most beautiful, the richest and wisest of persons, infallible, irresistible, aye, perhaps God or Christ. Sometimes the feeling of grandeur, the euphoria, is less fantastic and the patient imagines himself a great inventor, a statesman of power and wisdom, a writer of renown, etc. Suddenly, or perhaps gradually, the change comes; self-feeling drops into an abyss. "I am the most miserable of persons, the vilest sinner, hated and rightly by God and man, cause of suffering and misery. I am no good, no use, a horrible odor issues from me, I am loathsome to look at, etc., etc." Desperate suicidal attempts are made, and all the desires that tend to preserve the individual disappear, including appetite for food and drink, the power to sleep. It is the most startling of transitions; one can hardly realize that the dejected, silent person, sitting in a corner, hiding his face and hardly breathing, is the same individual who lately tore around the wards, happy, dancing, singing and boasting of his greatness of power. Indeed, is he the same individual? No wonder the ancients regarded such insanity as a possession by an evil spirit. We of a later day who deal with this disease on the whole are inclined to the belief that some internal factor of a physical kind is responsible, some neuronic shift, or some strange, visceral endocrinal disorder.