The modern science of pathology is usually regarded as dating from the earlier researches of Virchow, whose 'Cellular Pathology' was the outcome of a very careful and elaborate induction. Virchow, himself, felt a strong aversion to mere speculation. He endeavored to keep close to observation, and to relieve medical science from the control of fantastic theories, such as those of the _Naturphilosophen_ had been. Yet Virchow's researches were, as early as 1847, or still earlier, already under the guidance of a theoretical presupposition which he himself states as follows: "We have learned to recognize," he says, "that diseases are not autonomous organisms, that they are no entities that have entered into the body, that they are no parasites which take root in the body, but _that they merely show us the course of the vital processes under altered conditions_" ('dasz sie nur Ablauf der Lebenserscheinungen unter veränderten Bedingungen darstellen'). The enormous importance of this theoretical presupposition for all the early successes of modern pathological investigation is generally recognized by the experts. I do not doubt this opinion. It appears to be a commonplace of the history of this science. But in Virchow's later years this very presupposition seemed to some of his contemporaries to be called in question by the successes of recent bacteriology. The question arose whether the theoretical foundations of Virchow's pathology had not been set aside. And in fact the theory of the parasitical origin of a vast number of diseased conditions has indeed come upon an empirical basis to be generally recognized. Yet to the end of his own career Virchow stoutly maintained that in all its essential significance his own fundamental principle remained quite untouched by the newer discoveries. And, as a fact, this view could indeed be maintained. For if diseases proved to be the consequences of the presence of parasites, the diseases themselves, so far as they belonged to the diseased organism, were still not the parasites, but were, as before, the reaction of the organism to the _veränderte Bedingungen_ which the presence of the parasites entailed. So Virchow could well insist. And if the famous principle in question is only stated with sufficient generality, it amounts simply to saying that if a disease involves a change in an organism, and if this change is subject to law at all, then the nature of the organism and the reaction of the organism to whatever it is which causes the disease must be understood in case the disease is to be understood.