on his way, he met accidentally with Dr. Thomas Coxe, a physician of some repute at that time, who was attending his brother. The choice of a profession became the subject of a conversation between them, which determined him in favour of medicine; for in a letter addressed to Dr. Mapletoft, thirty years after this time, which forms the preface to one of his writings, he refers with much warmth to this conversation as the origin of his professional zeal, and, consequently, of whatever useful advances he had made in medicine. Thus his success, both in the practice and reformation of his art, may show the advantage of waiting till the faculties are fully matured, before they are exercised in a study which requires independence as well as vigour in thinking: for the circumstances of his family being sufficiently affluent to place him above the necessity of choosing a profession early, he had not turned his attention to physic till an age at which the medical education is generally almost completed. We are not, however, to believe in the justice of an accusation brought against him, that he had never studied his profession till he began to practise it; for though we do not know what particular line of study he pursued on his return to Oxford, it is clear from many passages in his works that he had studied the writings of the ancient physicians with no common care; and as his own show no defect of acquaintance with whatever real information had been collected before his time, we may reasonably conclude that this contemporary censure was mistaken or malicious. He certainly held the opinions of his modern predecessors in very little respect, for he does not often mention them, even for the purpose of confutation; and in the letter to Dr. Mapletoft already referred to, he says that he had found the best, and, in fact, the only safe guide, through the various perplexities he had met with in his practice, to be the method of actual observation and experiment recommended by Lord Bacon. This sentiment is often repeated in his works; but it surely does not countenance the idea that he had begun to practise without endeavouring to make what preparation he could, or would have had others follow such an example; for the charge against him goes to this length. The notion might arise from a foolish anecdote related by his admirer, Sir Richard Blackmore, of his having recommended Don Quixote as the best introduction he knew to the practice of medicine, which Sydenham must have intended as a jest, or perhaps as a sarcasm on the narrator himself.