Edward, the third son of the Rev. Stephen Jenner, was born May 17, 1749, in the vicarage-house of Berkeley in Gloucestershire, of which parish his father, a man of independent fortune, and of a family long established and esteemed in that neighbourhood, was incumbent. At the death of that parent in 1754, the care of Edward Jenner’s education devolved upon his eldest brother, Stephen, who succeeded to the living of Berkeley, and faithfully and affectionately discharged the duties of a father towards him. He began at a very early age to give tokens of that fondness and aptitude for the study of natural history, which first directed the choice of his profession; and afterwards led him, by steps which may be easily traced, to the discovery of a method of securing the constitution against the small-pox, by a remedy so mild as to be scarcely an inconvenience, yet so effectual as almost to have extinguished that disease in some countries where it has been energetically used. Having finished his school education and fixed upon a profession, Jenner was apprenticed at the usual age to Mr. Ludlow, a surgeon practising at Sodbury near Bristol; and in 1770, when nearly twenty-one, he came to London, and put himself under the tuition of John Hunter, in whose house he lived for two years, as much in the capacity of a friend as in that of a pupil, with great advantage to his professional studies. The intimacy between these two eminent men was very close and cordial, and subsisted till Hunter’s sudden death in 1793. It is attested by many letters from Mr. Hunter, which Jenner carefully preserved; his own were probably destroyed with the rest of Hunter’s papers by the late Sir Everard Home. Their correspondence relates chiefly to facts and experiments in natural history.