The growing interest in the public mind in favour of vaccination was of course everywhere extended to its author, who, in spite of several unworthy cabals, and attempts to deprive him of the credit of a discovery peculiarly his own, was received among all ranks with the highest distinction at home, and also gratified with various continental honours. If he had thought fit to settle in London, he might undoubtedly have secured wealth in proportion to his reputation; but he preferred the quiet enjoyment of rural life and domestic happiness. His death took place at Berkeley, from a sudden attack of apoplexy, in February, 1823, in the seventy-fourth year of his age. The latter years of his life were spent between Berkeley and Cheltenham, and in occasional visits to London, in the zealous prosecution of his favourite subjects of research, and successful endeavours to diffuse the blessings of his discovery more widely in his own and other lands. In England, however, these have not been so extensively felt as in some other countries where the form of government has given facilities for the enforcement of vaccination. The small-pox consequently prevails to a considerable extent in this country, and especially in London. Yet the annual number of deaths from small-pox within the bills of mortality is at present under 700; the largest number in one year since the general practice of vaccination having been 1299, in 1825. A century ago, when the population certainly did not reach half its present amount, the yearly average was 2000, the maximum being in 1796, when the mortality swelled to 3549. That this decrease is wholly due to vaccination cannot be doubted; the advantage, however, is partly indirect, and has arisen from the discontinuance of the practice of inoculating for the small-pox, which afforded security to individuals, but increased the general mortality by keeping alive a constant source of infection. But the most striking examples of the advantage derived from vaccination are to be found on the continent. Thus at Berlin, where the average annual amount of deaths from small-pox was 472 for the twenty years previous to 1802, and 1646 died in 1801, the mortality so speedily diminished after the enforcement of vaccination by law, that in 1821 and 1822 there was only one death in each year. These and similar instances which might be adduced from other countries, seem almost to warrant us in adopting the sanguine expectation of Jenner, that by means of his discovery this disgusting and dreadful malady, from which not four in a hundred of the human race wholly escaped, and which destroyed a tenth part of all that were born, and disfigured where it did not destroy, may yet be swept from the face of the earth.