From the sixteenth century Florida Indians had Negro blood, but from early part of the nineteenth century the Seminoles gained a large new infiltration of Negro blood from the numbers of slaves who fled to them and with whom they intermarried. The first Seminole war, therefore, in 1818 was not simply a defense of the frontiers against the Indians and a successful raid to drive Spain from Florida, it was also a slave raid by Georgia owners determined to have back their property. By 1815 Negroes from Georgia among the Creeks and Seminoles numbered not less than 11,000 and were settled along the Appalachicola river, many of them with good farms and with a so-called Negro “fort” for protection. The war was disastrous to Negroes and Indians but not fatal and in 1822 some 800 Negroes were counted among the Indians who inhabited the new territory seized from Spain. Pressure to secure alleged fugitives and Negroes from the Indians was kept up for the next three years and the second Seminole war broke out because the whites treacherously seized the mulatto wife of the Indian chief Osceola. The war broke out in 1837 and its real nature, as a New Orleans paper said in 1839, was to subdue the Seminoles and decrease the danger of uprisings “among the serviles.” Finally after a total cost of twenty million dollars the Indians were subdued and moved to the West and a part of the Negroes driven back into slavery, but not all.[132] Through the organization which came to be known as the Underground Railroad, thousands of slaves escaped through Kentucky and into the Middle West and thence into Canada and also by way of the Appalachian Mountains into Pennsylvania and the East. Not only were they helped by white abolitionists but they were guided by black men and women like Joshua Henson and Harriet Tubman.