The intention in offering for your perusal the preceding newspaper accounts of Dr. Brinkley's work in the opening months of the year 1920 was to show you what his views at that time were regarding the value of the gland operation which he has since made his life-work. The Chicago Tribune speaks of it as incidental to his general work as a surgeon. Dr. Brinkley himself speaks of shortly beginning an experiment upon an old man of 80. A year later he looked back upon a record of achievement of the most astounding results in operations performed upon men of 75, 80, and even 81. During this past year he has perfected his technique, implants the male glands exclusively into men and the female glands or ovaries into women, and has definitely selected the scrotum of the man as the only right place in which to introduce the goat-glands for the transplantation. You are here viewing the development of a great scientific discovery from the beginning of its employment upon human beings. Nor is there any reason to suppose that the year 1922 will produce no embellishment of value in the form of a wider application of the method. Some very striking limitations have been established during the past year's work. For instance: If the blood examination shows a positive Wasserman test for syphilis it is useless to transplant the glands, because they will certainly slough out. Active syphilis is antagonistic to the goat-tissue. Even latent syphilis, showing a negative Wasserman, is likely to produce a slough of the glands. Nothing should be concealed from the doctor, of course, and yet it has happened at the hospital at Milford that a patient on being questioned in advance of the operation has emphatically stated that he had never contracted syphilis, and three days later, after the transplantation, when the sloughing of the new glands had shown something definitely wrong with the blood, this patient admitted that he had not spoken the truth in the matter, but had contracted the disease many years previously. On the other hand, in Locomoter Ataxia, in which there is invariably a history of syphilis, the goat-glands take hold without exception, the efficacy of the transplantation in this disease, hitherto incurable by any means known to man, being due to the power of the new glands to cause a dissolving of scar-tissue, in the opinion of Dr. Abrams of San Francisco, who investigated the remarkable results attained by Dr. Brinkley in his cures of Locomoter Ataxia by the goat-gland operation.