Dr. Brinkley began his experiments in gland-transplanting upon animals in the year 1911, three years before the European War, using goats, sheep, and guinea-pigs as his subjects. He ran beyond the limits of his resources in this experimental work on animals, which was interrupted by his enlistment in the army, and assignment to service as First Lieutenant in the Medical Corps. Passed fit for Foreign Duty he was nevertheless unable to get across to France, and remained, like many another good surgeon, on duty in various southern camps. Returning to civilian life he took up his quest again, varying a general medical and surgical practice by continued observation and experiment in gland-transplantations upon animals, leaning ever more strongly towards the exclusive use of goats. About this time he heard of the work of Professor Steinach of Vienna in grafting the glands of rats, and producing changes in the character and appearance of the animals by inverting the process of nature and transplanting male glands into females, and vice versa, sometimes with success. He had followed with the greatest interest also the experiments of Dr. Frank Lydston of Chicago, who performed his first human-gland transplantation upon himself, an example of courage that falls not far short of heroism. But Dr. Brinkley was never favorably impressed with the idea of using the glands of a human being for the renovation of the life-force of another human being. He was looking to the young of the animal kingdom to furnish him with the material he proposed to use to improve the functioning of human organs, and more certainly as time passed he drew to the conclusion that in the goat, and in the goat alone, was to be found that gland-tissue which, because of its rapid maturity, potency, and freedom from those diseases to which humanity is liable, was most sure under right conditions of implantation to feed, nourish, grow into and become a part of, human gland-tissue.