Sir, besides the above commemorated, there are also other Observations; strenuously refuting the Operation on an Universal Medicine, partly in respect of the Age and strength of Man, partly by reason of the Sex, and other Circumstances, whilst a difference is to be made between the tender, and the Robust, whether from Nature, or from Education; or between the Male and Female, or between a Young Man and a Virgin, or between the Beginning, Middle, or End of Diseases; or it is to be understood whether a Disease, be inveterate, or the Sick be lately invaded; or lastly, whether the Ferment be promoted in this Disease, or be precipited in in another. Effervescency is made either in the Stomach or in the Intestines. Assuredly there are many contradictions of the Wonderful effect, of the Universal Medicine. For the greatest part of rational Physicians want the Perspicil of Thomas Didymus in their Fingers. Artist Indeed, Sir; you have philosophised rightly, and well, yea, Arthodoxly, against the universal Medicament, according to that notorious, and far spred proverb. As many Heads, so many Senses. For as Sweet sounding Musick delights not the Ears of every Midas; nor doth the Same History related please all Historians; nor of Bread and Wine, of the same Taste, is there a like relish in all Palats. So also the judgements of Skilful Men do strangely differ, touching the wonderful Effect of this Universal Medicine, on Humane and Metallick Bodies. For this Universal Medicine, in its way of Operating, vastly differs, from a particular Medicine, which may in some sense be called Universal, as the Herb Scurvy-grass, curing every Scorbutick marked with blew Spots; or Sorrel, healing every Scurvy, noted with red Spots; or Brook-lime, healing an Atrophia of that Kind, or Fumitory remedying Tumors of that Kind: and that especially with such Physicians, with whom the Observation you before recited, is of any esteem. Moreover, there is an exceeding great difference between the Universal Medicine of Philosophers, refreshing the vital Spirits, and between a Particular Medicament of Proletary-Curation, with which is corrected the venom of Humors; viz. such as boyles up against Nature, in this Man, Acid; in that Man, the Bitter is predominant; in one, what is Saline, in another, what is sharp, grow potent. But, if these Corrupt humors be not without all delay presently expelled out of the Body, by the ordinary Emunctories of Nature either by the Belly, or by Urine of the Bladder, or by the Sweat through the Pores, or by the Spittle of the Mouth, or by the Nostrils, assuredly the corruption of one, becomes the Generation of another, viz. of a Disease. For, from every spark, if we do not timely extinguish it, an exceding great burning will arise. Also, if there be a defect, of the Vital Spirits, it is impossible to effect this. Therefore the only care of a Conscientious Physician should be, how to deduce the motion of the Vital Spirits to a digestible natural Heat,