The circumstances attending the progress of the epidemic at Carlton House are worthy of notice, both on account of the extreme virulence which characterized the disease at that post, and also as no official record of this visitation of small-pox would be complete which failed to bring to the notice of your Excellency the undaunted: heroism displayed by a young officer of the Hudson Bay Company who was in temporary charge of the station. At the breaking out of the disease, early in the month of August, the population of Carlton: numbered about seventy souls. Of these thirty-two persons caught the infection, and twenty-eight persons died. Throughout the entire period of the epidemic the officer already alluded to, Mr. Wm. Traill, laboured with untiring perseverance in ministering to the necessities of the sick, at whose bedsides he was to be found both day and night, undeterred by the fear of infection, and undismayed by the unusually loathsome nature of the disease. To estimate with any thing like accuracy the losses caused among the Indian tribes is a matter of considerable difficulty. Some tribes and portions of tribes suffered much more severely than others. That most competent authority, Pere Lacombe, is of opinion that neither the Blood nor Blackfeet Indians had, in proportion to their numbers, as many casualties as the Crees, whose losses may be safely stated at from 600 to 800 persons. The Lurcees, a small tribe in close alliance with the Blackfeet, suffered very severely, the number of their tents being reduced from fifty to twelve. On the.' other hand, the Assineboines, or Stonies of the Plains, warned by the memory of the former epidemic, by which they were almost annihilated, fled at the first approach of the disease, and, keeping far out in the south-eastern prairies, escaped the infection altogether. The very heavy loss suffered by the Lurcees to which I have just alluded was, I apprehend, due to the fact that the members of this tribe have long been noted as persons possessing enfeebled constitutions, as evidenced by the prevalence of goitre almost universally amongst them. As a singular illustration of the intractable nature of these Indians, I would mention that at the period when the small-pox was most destructive among them they still continued to carry on their horse-stealing raids against the Crees and half-breeds in the neighbourhood of Victoria Mission. It was not unusual to come upon traces of the disease in the corn-fields around the settlement, and even the dead bodies of some Lurcees were discovered in the vicinity of a river which they had been in the habit of swimming while in the prosecution of their predatory attacks. The Rocky Mountain Stonies are stated to have lost over fifty souls. The losses sustained by the Blood, Blackfeet, and Peagin tribes are merely conjectural; but, as their loss in leading men or chiefs has been heavy, it is only reasonable