to presume that the casualties suffered generally by those tribes have been proportionately severe. Only three white persons appear to have fallen victims to the disease, one an officer of the Hudson Bay Company service at Carlton, and two members of the family of the Rev. Mr. McDougall, at Victoria. Altogether, I should be inclined to estimate the entire loss along the North Saskatchewan, not including Blood, Blackfeet, or Peagin Indians, at about 1200 persons. At the period of my departure from the Saskatchewan, the beginning of-the present year, the disease which committed such terrible havoc among the scanty population of that region still lingered in many localities. On my upward journey to the Rocky Mountains I had found the forts of the Hudson Bay Company free from infection: On my return journey I found cases of small-pox in the Forts, of Edmonton, Victoria, and Pitt--cases which, it is true, were of a milder description than those of the autumn and summer, but which, nevertheless, boded ill for the hoped for disappearance of the plague beneath the snows and cold of winter. With regard to the supply of medicine sent by direction of the Board of Health in Manitoba to the Saskatchewan, I have only to remark that I conveyed to Edmonton the portion of the supply destined for that station. It was found, however, that many of the bottles had been much injured by frost, and I cannot in any way favourably notice either the composition or general selection of these supplies. Amongst the many sad traces of the epidemic existing in the Upper Saskatchewan I know of none so touching as that which is to be found in an assemblage of some twenty little orphan children gathered together beneath the roof of the sisters of charity at the settlement of St. Albert. These children are of all races, and even in some instances the sole survivors of what was lately a numerous family. They are fed, clothed, and taught at the expense of the Mission; and when we consider that the war which is at present raging in France has dried up the sources of charity from whence the Missions of the North-west derived their chief support, and that the present winter is one of unusual scarcity and distress along the North Saskatchewan, then it will be perceived what a fitting object for the assistance of other communities is now existing in this distant orphanage of the North.