I cannot close this notice of the epidemic without alluding to the danger which will arise in the spring of introducing the infection into Manitoba. As soon as the prairie route becomes practicable there will be much traffic to and from the Saskatchewan--furs and robes will be introduced into the settlement despite the law which prohibits their importation. The present quarantine establishment at Rat Creek is situated too near to the settlement to admit of a strict enforcement of the sanitary regulations. It was only in the month of October last year that a man coming direct from Carlton died at-this Rat Creek, while his companions, who were also from the same place, and from whom he caught the infection, passed on into the province. If I might suggest the course which appears to me to be the most efficacious, I would say that a constable stationed at Fort Ellice during the spring and summer months who would examine freighters and others, giving them bills of health to enable them to enter the province, would effectually meet the requirements of the situation. All persons coming from the West are obliged to pass close to the neighbourhood of Fort Ellice. This station is situated about 170 miles west of the provincial boundary, and about 300 miles south-east of the South Saskatchewan, forming the only post of call upon the road between Carlton and Portage la-Prairie. I have only to add that, unless vaccination is made compulsory among the half-breed inhabitants, they will, I fear, be slow to avail themselves of it. It must not be forgotten that with the disappearance of the snow from the plains a quantity of infected matter--clothing, robes, and portions of skeletons--will again be come exposed to the atmosphere, and also that the skins of wolves, etc., collected during the present winter will be very liable to contain infection of the most virulent description. The portion of-your Excellency's instructions which has reference to the Indian tribes of the Assineboine and Saskatchewan regions now claims my attention.