A quotation from Hecker's "Epidemics of the Middle Ages" will be a sufficient summary of what was reported of the plague in eastern countries before its arrival in Europe. "Cairo lost daily, when the plague was raging with its greatest violence, from 10 to 15,000, being as many as, in modern times, great plagues have carried off during their whole course. In China more than thirteen millions are said to have died, and this is in correspondence with the certainly exaggerated accounts from the rest of Asia. India was depopulated. Tartary, Mesopotamia, Syria, Armenia were covered with dead bodies; the Kurds fled in vain to the mountains. In Caramania and Cæsarea none were left alive. On the roads, in the camps, in the caravansaries unburied bodies were alone to be seen. . . . In Aleppo 500 died daily; 22,000 people and most of the animals were carried off in Gaza within six weeks. Cyprus lost almost all its inhabitants; and ships without crews were often seen in the Mediterranean, as afterwards in the North Sea, driving about and spreading the plague wherever they went ashore."[3] There can be little doubt that the contagion was first spread by means of the great trade routes of the East. The lines of commerce of European countries with India, China, and Asiatic countries generally are first definitely described in 1321 by Marino Sanudo, a Venetian, in a work addressed to Pope John XXI., not thirty years before the outbreak of [p003] the pestilence.[4] His object was to indicate the difficulties and dangers which then beset the traffic of the mercantile world with the East. In so doing he pointed out that the ancient centre of all trade with the far East was Bagdad. To and from this great depôt of Oriental merchandise all the caravan routes led; but, at the time when Sanudo wrote, the incursion of barbarian hordes into Central Asia had rendered trade along these roads difficult and unsafe. Two trading tracts are in particular named by the author as the chief lines of communication. One ran from Bagdad over the plains of Mesopotamia and Syria to Lycia,[5] where the goods were purchased by the Italian merchants. This, the best known route, was the shortest by which the produce of China and India could be conveyed to the European markets; but in the fourteenth century it was the most perilous. The second route also started from Bagdad, and having followed the Tigris to its sources in Armenia, passed on either to Trebizond and other ports of the Black Sea, or taking the road from the Caspian, upon the other side of the Caucasus, passed to the Genoese and other flourishing Italian settlements in the Crimea.